DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kcna6a and Shawl

DIOPT Version :9

Sequence 1:	NP_001124098.1	Gene:	kcna6a / 795490	ZFINID:	ZDB-GENE-080722-21	Length:	475	Species:	Danio rerio
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	171/546 - (31%)
Similarity:	249/546 - (45%)	Gaps:	163/546 - (29%)

- Green bases have known domain annotations that are detailed below.

Zfish    33 VTINISGLRFETQLKTLARYPNTLLGDPIKRMRFFDPLRNEFFFDRNRPSFDAILYYYQSGGRLR 97
            :.:|:||:|:||...||.:.|.|.|....:.:..:||:.||:||||:...|..||.||:: |:|.
  Fly     7 IILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKLH 70

Zfish    98 RPINVPVDMFLDEIKFYEIGDDVI-----------KHFQEDEGLLK----EDERP---------- 137
            .|.:|...:|.:|::|:.:..:.:           :..|....:|.    |:|:|
  Fly    71 YPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLFG 135

Zfish   138 ----LPSNE------FKRQIWLLFEHPDSSGAARIIAIVSVMVILISIIIFCIETLPEFRED--D 190
                |.:.|      .|.:||.:|:.|.||..|:|:|.:||..|.:|:|.||::|.|.||.|  .
  Fly   136 FEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPS 200

Zfish   191 RVFDNHLP-----------------------------------------------ANSTTSVQR- 207
            ...|.|.|                                               .|.|.|.|.
  Fly   201 GAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQAT 265

Zfish   208 -----------------------------------------LSAYTDP---FFLLETICIVWFCF 228
                                                     :..|..|   ||.:|.:|.|||..
  Fly   266 PIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFFI 330

Zfish   229 ELFIRFLACPSKPTFFKDIMNTIDIVAIMPYFITLSLELGEVQSNQQQTTSLAILRVIRLVRVFR 293
            |:.||.:..|:...|.|..:|.||..|.:.::..:...:||.         ..:|....:||:.|
  Fly   331 EVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEY---------TGLLEAFSIVRIMR 386

Zfish   294 IFKLSRHSKGLQILGQTLRASMRELGLLIFFLIIGIILFSSAVYFAE--ADDPETSFTSIPDAFW 356
            :|||:|||.||:||..|.:||.:||.||:|||::||:.|:|..|:||  .|:|:..|.|||...|
  Fly   387 LFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLW 451

Zfish   357 WAVVSMTTVGYGDMYPVTIGGKIVGSMCAIAGVLTIALPVPVIVSNFNYFYHREHNEADQVEYTH 421
            ||:|:||||||||:.|.|..|..||::||:|||||||||||||||||:.||  .|.:|
  Fly   452 WAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY--SHTQA------- 507

Zfish   422 VTCGRS---------LPMQCDRNKSD 438
                ||         ||::..|.|.:
  Fly   508 ----RSKLPKKRRRVLPVEQPRRKRE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcna6a	NP_001124098.1	BTB	33..122	CDD:197585	31/99 (31%)
		BTB_2	33..121	CDD:280393	31/87 (36%)
		Ion_trans	211..411	CDD:278921	96/204 (47%)
		Ion_trans_2	<350..401	CDD:285168	35/50 (70%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	31/92 (34%)
		BTB_2	7..97	CDD:280393	31/90 (34%)
		Ion_trans	307..506	CDD:278921	97/209 (46%)
		Ion_trans_2	<449..499	CDD:285168	35/49 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810