Protein Alignment BIRC7 and Diap1

DIOPT Version :10

• Sequence 1: XP_054179986.1
• Gene: BIRC7 / 79444
• HGNCID: 13702
• Length: 351
• Species: Homo sapiens
• Sequence 2: NP_524101.2
• Gene: Diap1 / 39753
• FlyBaseID: FBgn0260635
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 373
• Identity: 86/373 - (23%)
• Similarity: 125/373 - (33%)
• Gaps: 107/373 - (28%)

Human     5 DSAKCLHRGPQPSHWAAGDGPTQE--RCGP-------RSLGS------------PVLGLDTCRAW 48
            |..||...|.:...|...|.|..|  |..|       |:..:            |.:..|.|.|.
  Fly    76 DKVKCFFCGVEIGCWEQEDQPVPEHQRWSPNCPLLRRRTTNNVPINAEALDRILPPISYDICGAN 140

Human    49 D-----------------------------HVDGQILGQLRP---------------LTEEEEEE 69
            |                             :..|.:.|...|               .|.:.:.|
  Fly   141 DSTLEMREHAYAEGVIPMSQLIQSIGMNAVNAAGSVTGTAAPQPRVTVATHASTATQATGDVQPE 205

Human    70 GAGATLSRG---PAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFCYGGL 131
            ....:.:.|   |.:|....|..||.:|..||...:..|..||.||||:||..|:||||.|.|||
  Fly   206 TCRPSAASGNYFPQYPEYAIETARLRTFEAWPRNLKQKPHQLAEAGFFYTGVGDRVRCFSCGGGL 270

Human   132 QSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPAS 196
            ..|...|:||.:||.|...|:|:...||:.::.:|  ....:|.     ||.|:::.:.....||
  Fly   271 MDWNDNDEPWEQHALWLSQCRFVKLMKGQLYIDTV--AAKPVLA-----EEKEESSSIGGVAVAS 328

Human   197 GYPELPTPRREVQSESAQEPGAGP--GPPGEPGMWRR-------------SCGGCRRRGRARCAW 246
            ........:..:.||.|......|  .|.....::.:             |.|.........|
  Fly   329 TQASEEEQQTSLSSEEAVSGDVAPSVAPTAATRIFNKIVEATAVATPSTNSSGSTSIPEEKLC-- 391

Human   247 TAPCPSSLCRAATWSVLSVPPAC----SCAPSAEPPSAAACAPSCPRP 290
                  .:|..|.::...:|  |    :||..|.  |...| |.|.:|
  Fly   392 ------KICYGAEYNTAFLP--CGHVVACAKCAS--SVTKC-PLCRKP 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BIRC7	XP_054179986.1	BIR	88..155	CDD:237989	32/66 (48%)
Diap1	NP_524101.2	BIR	44..112	CDD:197595	10/35 (29%)
		BIR	226..295	CDD:197595	33/68 (49%)
		RING-HC_IAPs	388..427	CDD:438173	12/51 (24%)