DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Igfals and Fili

DIOPT Version :9

Sequence 1:	NP_445781.3	Gene:	Igfals / 79438	RGDID:	68429	Length:	603	Species:	Rattus norvegicus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	344	Identity:	105/344 - (30%)
Similarity:	172/344 - (50%)	Gaps:	33/344 - (9%)

- Green bases have known domain annotations that are detailed below.

  Rat   219 ELRELDLSRNALRSVKANVFVHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLME 283
            |.:.::|:.|.:|:::.::..:: :|:.|.|.:|:|..:..:.|.....||.|:||.|.|:.|.:
  Fly    74 ETKYINLTVNRIRTLEFSLPFYM-KLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHK 137

  Rat   284 DTFPGLLGLHVLRLAHNAIASLRPRTFKDLHFLEELQLGHNRIRQLGERTFEGLGQLEVLTLNDN 348
            ..|.||..|.:|.|:.|.|.::.|....||..|.||.|.:|.|..|.:..|:|:..||||...:|
  Fly   138 HAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNN 202

  Rat   349 QITEVRVGAFSGLFNVAVMNLSGNCLRSLPERVFQGLDKLHSLHLEHSCLGHVRLHTFAGLSGLR 413
            ::.:|.......|..:..:::|.|.:..:....|:||.:|.:|.::.:.:..:.|..|.||..|:
  Fly   203 RLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLK 267

  Rat   414 RLFLRDNSISSIEEQSLAGLSELLELDLTTNRLTHLPRQLFQGLGHLEYLLLSYNQLTTLSAEVL 478
            .|.|.||:::.:..|.|:.||.|..|:|..||.:.||...|..|.||..|.||.          |
  Fly   268 HLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSR----------L 322

  Rat   479 GPLQ----RAFWLDISHNHLETL-----------AEGLFSSLGRLRYLSLRNNSLQTF----SPQ 524
            ..||    |||   :.:.||:||           ...||.....:..:.:::|||||.    .|.
  Fly   323 DFLQRIDSRAF---VDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPV 384

  Rat   525 PGLERLWLDANPWDCSCPL 543
            ..|::|:|..||..|:|.|
  Fly   385 DQLQKLYLGDNPLQCNCSL 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Igfals	NP_445781.3	LRRNT	40..78	CDD:214470
		leucine-rich repeat	57..75	CDD:275380
		PLN00113	68..>494	CDD:215061	85/278 (31%)
		LRR 1	75..96
		leucine-rich repeat	79..99	CDD:275380
		LRR 2	99..120
		leucine-rich repeat	103..123	CDD:275380
		LRR 3	123..144
		LRR 4	147..168
		LRR 5	171..192
		leucine-rich repeat	175..195	CDD:275380
		LRR 6	195..216
		leucine-rich repeat	196..219	CDD:275380	105/344 (31%)
		LRR 7	219..240		4/20 (20%)
		leucine-rich repeat	220..243	CDD:275380	3/22 (14%)
		LRR 8	243..264		6/20 (30%)
		leucine-rich repeat	244..267	CDD:275380	6/22 (27%)
		LRR 9	267..288		9/20 (45%)
		leucine-rich repeat	268..291	CDD:275380	11/22 (50%)
		LRR 10	291..312		6/20 (30%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		LRR 11	315..336		8/20 (40%)
		leucine-rich repeat	316..339	CDD:275380	9/22 (41%)
		LRR 12	339..360		6/20 (30%)
		leucine-rich repeat	340..363	CDD:275380	7/22 (32%)
		LRR 13	363..384		3/20 (15%)
		leucine-rich repeat	364..387	CDD:275380	5/22 (23%)
		LRR 14	387..408		4/20 (20%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
		LRR 15	411..432		7/20 (35%)
		leucine-rich repeat	412..435	CDD:275380	8/22 (36%)
		LRR 16	435..456		8/20 (40%)
		leucine-rich repeat	436..459	CDD:275380	9/22 (41%)
		LRR 17	459..480		6/20 (30%)
		leucine-rich repeat	460..481	CDD:275380	5/20 (25%)
		LRR 18	483..504		9/31 (29%)
		leucine-rich repeat	484..507	CDD:275380	8/33 (24%)
		LRR_8	486..536	CDD:404697	15/64 (23%)
		LRR 19	507..528		6/24 (25%)
		TPKR_C2	535..578	CDD:417692	5/9 (56%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	3/22 (14%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR_8	120..180	CDD:404697	24/59 (41%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	63/205 (31%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	10/36 (28%)
		LRR_8	337..397	CDD:404697	16/59 (27%)
		leucine-rich repeat	339..360	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010