DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myh10 and Mhc

DIOPT Version :9

Sequence 1:XP_008766103.1 Gene:Myh10 / 79433 RGDID:71000 Length:2007 Species:Rattus norvegicus
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1981 Identity:786/1981 - (39%)
Similarity:1194/1981 - (60%) Gaps:91/1981 - (4%)


- Green bases have known domain annotations that are detailed below.


  Rat     8 EDPERYLFV-------DRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAEN 65
            |||..||||       |::..|:        :||..|||.|:.|:....||..:||.|.|.| :.
  Fly    11 EDPTPYLFVSLEQRRIDQSKPYD--------SKKSCWIPDEKEGYLLGEIKATKGDIVSVGL-QG 66

  Rat    66 GKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKN 130
            |:...:..:.::|:|||||.|:||||::|.||...|||||:.|||:.|||||||||||.|||||.
  Fly    67 GEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKR 131

  Rat   131 LPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYL 195
            .|:|:....:|||||:|:|:||||:|||:.||..||.:..:||:|.||||||||||||||||.|.
  Fly   132 YPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYF 196

  Rat   196 AHVASSHKGRKDHNIPQESPKPVKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINF 260
            |.|.:|.|          :.:..|.:|.||.|::|.||:||:|||||||:|||||||||||||:|
  Fly   197 ATVGASKK----------TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHF 251

  Rat   261 DVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKS-DLLLEGFNNYRFLSNGY 324
            ..||.:.||:||||||||:|.:.|...||::|||||::||:...:|. .||.:...:|..:|.|.
  Fly   252 GPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGK 316

  Rat   325 IPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQ 389
            :.:....|.:.|..|.:|..|:||:.:|...:.::.::|:..|.:.||:....:||.........
  Fly   317 VTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGG 381

  Rat   390 KLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKAL 454
            ::..|.|.:..|..:.:|.||||||.::|.:.:..:|...::.||.|..::|||:|||.:.|:.|
  Fly   382 RVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETL 446

  Rat   455 DRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFI 519
            | |:::...|||:||||||||||.|.|||||||:|||||||.|||.||:||||||:||||:|.||
  Fly   447 D-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFI 510

  Rat   520 DFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQ-GSHSKFQKPRQLK--- 580
            |||:||..||||||:|.   |:|::|:||..||||||:||.|||.... |..:.||||:..|   
  Fly   511 DFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQ 572

  Rat   581 DKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSV 645
            ..|.|.|.||||.|.|....||.||.|||||.|.....:|.::.:.|::.|....          
  Fly   573 QAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQ---------- 627

  Rat   646 SGLHEPPVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCI 710
                             :|..|.|.|...| |.|.|.||...|||.|..||.|||:|.|:|||||
  Fly   628 -----------------SGGGEQAKGGRGK-KGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCI 674

  Rat   711 IPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGK 775
            |||..|:.|.:|.|||:.||.||||||||||||:|||||:::.:|:.||:|:.|..: :|....|
  Fly   675 IPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKLL-QGVEKDK 738

  Rat   776 QACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKK 840
            :|.|.:|:.::|..:.||:|.:|:|||||||..:||.||.::..|:.:.||..||||:||.|.|.
  Fly   739 KATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKL 803

  Rat   841 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKE---KQTKV 902
            |:|..||||:|||...||:||.|.|::::.||||||.|:|.|:|:...:|:..|.:|   .:.||
  Fly   804 QEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAEELHAAEVKV 868

  Rat   903 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV-EEEE 966
            ..|||.:..|   ||.||..|.:.|..|.....:.:|..|:|.|:|.:||..|.|::.|: :||:
  Fly   869 RKELEALNAK---LLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDIQERLTQEED 930

  Rat   967 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKE 1031
            .|||:.| :|||....|..|::.:::.|...||.:.:|.|.:.:|:.:.:|:...::..:|..||
  Fly   931 ARNQLFQ-QKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDELINKLNKE 994

  Rat  1032 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1096
            ||:..:...:...:|...|:|..:|.|::.|.|..:.:||:.|::|:|.|.::||:|||::|:..
  Fly   995 KKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSKRKVEGDLK 1059

  Rat  1097 DLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDETLHKNNALKVARELQAQIAELQEDFESE 1161
            ..|:.:|:|:....||:..:.:|::||....|:.:||.:......:..:||||:|.||:|:.|:|
  Fly  1060 LTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAE 1124

  Rat  1162 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEDETKNHEAQIQ 1226
            :.:|.|||||:.||:.|||.|...||:....|:||.||..|||.|:::|::.||:....||:.:.
  Fly  1125 RQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEANIQHESTLA 1189

  Rat  1227 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1291
            ::|::|..|:.|::||::|..:.||..||.|........:|...|..:...||..|...|:|...
  Fly  1190 NLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEKIAKQLQHT 1254

  Rat  1292 VQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEEAEKKGMKFAKDAAGLESQLQDTQELLQ 1356
            :.|:.:|:.|.:|...:......||..|..::...|||||.:..:.:|....|.:||:||:.|..
  Fly  1255 LNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLAD 1319

  Rat  1357 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD-LGTIEG 1420
            ||:|::..|..:.|.||.:.::|:||.|||.|.:.:|::|:....::....:.|.:.| :...|.
  Fly  1320 EESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYESDGVARSEE 1384

  Rat  1421 LEEAKKKL---LKDVEALSQRLEEKVLAYDKLEKTKNRLQQELDDLTVDLDHQRQIVSNLEKKQK 1482
            |||||:||   |.:.|...:.|.:|.:.   |||||.||..|::||.:::|....|.:..|||||
  Fly  1385 LEEAKRKLQARLAEAEETIESLNQKCIG---LEKTKQRLSTEVEDLQLEVDRANAIANAAEKKQK 1446

  Rat  1483 KFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1547
            .||:::.|.|......|.|.|.::.|.|...|:...|..|.||..|..|...|:||.|..:::||
  Fly  1447 AFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKDL 1511

  Rat  1548 MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1612
            :....:.|:|:||:||:::.||.:.:|::..|||.|..|:..|:..||.::.:..::.:.:|.:|
  Fly  1512 LDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRIQ 1576

  Rat  1613 TRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1677
            .::|:.|..::...:.:..::|.||.|.|.:|.|:..|||:|.|:.:||..::.||||..|..|.
  Fly  1577 EKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKN 1641

  Rat  1678 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1742
            :::.|.|:||.|..|||.:.:||:...|...||::..:|:.|:.:.:..|..::|.||.|||   
  Fly  1642 IKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQ--- 1703

  Rat  1743 ELAD--EIANSASGKSALLD-EKRRLEARIAQLEEELEE---EQSNMELLNDRFRKTTLQVDTLN 1801
            ||||  |..|..|.::|.:. .||:||:.:..|..:|:|   |..|.|   ::.:|..:....|.
  Fly  1704 ELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE---EKAKKAMVDAARLA 1765

  Rat  1802 TELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1866
            .||.||:..||..:..|:.||:|.|||:.:|.|.|.......|..|..||.::.:||.:|:.|.:
  Fly  1766 DELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQR 1830

  Rat  1867 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1931
            ..|.|.|.:|::|:::||:..|.|::|::.::.::.::|...::|..|||:|||||.|....|..
  Fly  1831 RHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKF 1895

  Rat  1932 RKLQRELDDATEANEGLSREVSTLKNRLRRG 1962
            ||.|:||::|.|..:...:.:|..:.:.|.|
  Fly  1896 RKAQQELEEAEERADLAEQAISKFRAKGRAG 1926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myh10XP_008766103.1 Myosin_N 34..72 CDD:280832 14/37 (38%)
Myosin_head 87..802 CDD:278492 346/719 (48%)
MYSc_Myh10 99..802 CDD:276952 339/707 (48%)
Myosin_tail_1 879..1959 CDD:279860 364/1093 (33%)
DUF2317 <1142..1253 CDD:302887 47/110 (43%)
ApoLp-III_like 1224..1371 CDD:304399 42/146 (29%)
GBP_C <1535..1641 CDD:303769 31/105 (30%)
coiled coil 1631..1641 CDD:293879 4/9 (44%)
DUF106 <1676..>1727 CDD:303007 16/50 (32%)
DUF2570 1800..>1898 CDD:305162 35/97 (36%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 14/37 (38%)
MYSc 81..777 CDD:214580 360/738 (49%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 339/707 (48%)
Myosin_tail_1 842..1897 CDD:279860 356/1067 (33%)
V_Alix_like 1557..1877 CDD:187408 104/325 (32%)
ATP-synt_B <1671..1771 CDD:304375 33/105 (31%)
TMPIT 1739..>1825 CDD:285135 29/88 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.720

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