Protein Alignment TFEB and RTG3

DIOPT Version :9

• Sequence 1: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_009447.1
• Gene: RTG3 / 852171
• SGDID: S000000199
• Length: 486
• Species: Saccharomyces cerevisiae
• Alignment Length: 357
• Identity: 91/357 - (25%)
• Similarity: 139/357 - (38%)
• Gaps: 123/357 - (34%)

Human    62 PPTPAINTPVHFQSPPPVPGEVLKVQ-------SYLENPTSYHLQQSQHQKVREYLS------ET 113
            |...|:|||:..|       |.||.:       .:..:.|.|:|.......:...::      .|
Yeast   143 PVDRAMNTPLQQQ-------EGLKAELPHDFLFQHGTDDTMYNLTDDLSSSLSSSINSDMMTPNT 200

Human   114 YGNKFAAH---ISPAQ-GSPKPPPAASP--GVRAGHVLSSSAGNSAPNSPMAM-LHIGSNPEREL 171
            |.:.|:.:   :.||. .|...|...||  ..|||..||||..:.:.|:|... ..|.||
Yeast   201 YSSSFSYNPQSLGPASVSSTYSPKVRSPSSSFRAGSFLSSSFRHGSINTPRTRHTSISSN----- 260

Human   172 DDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKREL 236
              :.:||               .|.::|                ..|.|:||..
Yeast   261 --MTENI---------------GPGSVP----------------KILGGLTSDE----------- 281

Human   237 TDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKA----NDL--DVRWNKGTILKAS 295
                     |.|:|::.||.:|||||..|..:|||||.|:|.:    :||  .::.|||.||..:
Yeast   282 ---------KLRRKREFHNAVERRRRELIKQKIKELGQLVPPSLLNYDDLGKQIKPNKGIILDRT 337

Human   296 VDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQEL-EMQARVHGL-PTT----SPSGMNMAE 354
            |:|::.:      :..||..:|:    .|.|..:|:|| |.::.|..| |.|    :.||.|.:|
Yeast   338 VEYLQYL------AEILEIQARK----KKALLAKIKELEEKKSSVAALSPFTNNHHASSGQNNSE 392

Human   355 ----------------LAQQVVKQELPSEEGP 370
                            :.:|..|.||.:.|.|
Yeast   393 NSEERIIDIRSVPNALMNEQNSKAELHNWEPP 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..175	CDD:292573	33/132 (25%)
		HLH	247..307	CDD:238036	26/65 (40%)
		DUF3371	335..471	CDD:288684	14/57 (25%)
RTG3	NP_009447.1	bHLHzip_USF_MITF	289..349	CDD:381393	24/65 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I3421
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940