Protein Alignment TFEB and tfeb

DIOPT Version :10

• Sequence 1: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Sequence 2: XP_031752001.1
• Gene: tfeb / 780105
• XenbaseID: XB-GENE-982675
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 490
• Identity: 288/490 - (58%)
• Similarity: 350/490 - (71%)
• Gaps: 71/490 - (14%)

Human    15 MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPT--PAINTPVHFQSPP 77
            ||||||||||||||||||||||||:|||...|::||....       |.|  |||:||..||:||
 Frog    43 MASRIGLRMQLMREQAQQEEQRERVQQQHQQHFLQQHHIV-------PVTASPAISTPASFQAPP 100

Human    78 PVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPA-ASPGVRA 141
            |||.|||:||::|||||.||||||:.:|||:|||:|||||||||::|.:.||||||| |||..||
 Frog   101 PVPVEVLEVQTHLENPTIYHLQQSRDKKVRDYLSDTYGNKFAAHLNPLRLSPKPPPAPASPAHRA 165

Human   142 GHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLN 206
            .. |||||||||||||||.:::.||.  |:||||||||.|||:.||..|.:.||||||.|||||.
 Frog   166 AR-LSSSAGNSAPNSPMARMNLCSNV--EMDDVIDNIMSLDDMFGYPEPAISMPNTLPFSSSHLG 227

Human   207 VYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKE 271
            :||.:|:::.::|||||:||||||..||||||||:|||.:||||||.||:|||||||||||||||
 Frog   228 LYSDNPRLSDTVVGVTSNSCPADLAIKRELTDAENRALVRERQKKDTHNMIERRRRFNINDRIKE 292

Human   272 LGMLIPKANDL-DVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEM 335
            ||.||||.|:| |.||||||||:||||||:.|||:.|||||||.|||:||:.||||.|||||||.
 Frog   293 LGTLIPKTNELSDTRWNKGTILRASVDYIKHMQKEQQKSRELETHSRQLELANKQLLLRIQELER 357

Human   336 QARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQ 400
            ||::||||.:||.|::.|:    .:|||..|                   :|::..|
 Frog   358 QAQMHGLPASSPHGLSPAD----HMKQESNS-------------------IPSIQQQ-------- 391

Human   401 PPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGHGS------PFPSLSKKDLDLMLLDDSLL-- 457
                   |..:...||       ...||.||  |:.|      .|||||:.:|||||::|::|
 Frog   392 -------LVATSQASF-------QMDYPAPL--GYQSNTSVDTSFPSLSRTELDLMLMEDTMLTS 440

Human   458 -PL-ASDPLLSTMSPEASKASSRRSSFSMEEGDVL 490
             || |.||::||:||:.|||||||||||::|.|.|
 Frog   441 DPLMACDPVMSTLSPDTSKASSRRSSFSIDEVDGL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..176	CDD:464952	106/160 (66%)
		bHLHzip_TFEB	240..330	CDD:381497	70/90 (78%)
		DUF3371	335..487	CDD:463372	57/161 (35%)
tfeb	XP_031752001.1	MITF_TFEB_C_3_N	46..197	CDD:464952	106/160 (66%)
		bHLHzip_TFEB	261..352	CDD:381497	70/90 (78%)
		DUF3371	357..471	CDD:463372	57/160 (36%)