Protein Alignment TFEB and tfeb

DIOPT Version :9

• Sequence 1: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_001244121.1
• Gene: tfeb / 562289
• ZFINID: ZDB-GENE-090807-3
• Length: 493
• Species: Danio rerio
• Alignment Length: 509
• Identity: 284/509 - (55%)
• Similarity: 348/509 - (68%)
• Gaps: 51/509 - (10%)

Human    15 MASRIGLRMQLMREQAQQEEQRERMQQQAV-MHYMQQQQQQQQQQLGGP--PTPAINTPVHFQSP 76
            |:||||||:||||:|.||||||||.||||| ||||       |.::.||  |||||:.|.|||.|
Zfish     1 MSSRIGLRLQLMRDQMQQEEQRERQQQQAVSMHYM-------QHRMPGPPEPTPAISAPTHFQGP 58

Human    77 PPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAA------ 135
            ..||.||||||::|||||.||::|||.|:|:||||.||..|.|.|...:...|.|||..
Zfish    59 MQVPVEVLKVQTHLENPTDYHIRQSQRQQVKEYLSTTYATKQAVHAVTSLVQPSPPPMVQAQTGS 123

Human   136 ------SPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRL----DDVLGYINP 190
                  ||.:|. ..|.:||||||||||||||:|.|:.|.|:||:||||:.|    ||:..|.:|
Zfish   124 APPNMHSPCMRT-EQLMNSAGNSAPNSPMAMLNISSSHENEMDDLIDNIISLQSSYDDIQAYNDP 187

Human   191 EMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHN 255
            .:|||||||||||||:||:. |.::.|.:.:||:||||:|..||||:|.|:||:|||||||||||
Zfish   188 VVQMPNTLPLSSSHLDVYTG-PGMSGSAIAMTSNSCPANLAIKRELSDVEARAMAKERQKKDNHN 251

Human   256 LIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLE 320
            ||||||||||||||||||.:|||.|||||||||||||:||||||:|||||:|::||:||:.||:|
Zfish   252 LIERRRRFNINDRIKELGTMIPKTNDLDVRWNKGTILRASVDYIKRMQKDVQRTREVENNFRRME 316

Human   321 MTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVP---- 381
            |.||||||||||||.||::||||:.||||:...:.....:|||...||   ..|...:.:|
Zfish   317 MANKQLWLRIQELERQAQIHGLPSNSPSGLTNTDHQNPFIKQESSPEE---NHLQHQSHLPPRYP 378

Human   382 --DPEPLPA------LPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAP-GH-G 436
              .|:|.|.      |.||.||..|....|  .|.|.:.||...   |.|.|||.:.|.. |. |
Zfish   379 QQHPQPHPQLHQHQHLHPQPPLQYPAVGSS--QHFDLAQSLDLC---DGGIPGYQDGLGDLGFLG 438

Human   437 SPFPSLSKK-DLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDV 489
            .....:.|| :|..:|::::|.||..|||||.||||||..||||||||:|:.|:
Zfish   439 GGIAQMGKKSELSFLLMEEALSPLGGDPLLSAMSPEASVDSSRRSSFSIEDSDI 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..175	CDD:292573	97/171 (57%)
		HLH	247..307	CDD:238036	54/59 (92%)
		DUF3371	335..471	CDD:288684	53/150 (35%)
tfeb	NP_001244121.1	MITF_TFEB_C_3_N	4..168	CDD:292573	97/171 (57%)
		HLH	243..303	CDD:238036	54/59 (92%)
		DUF3371	332..489	CDD:288684	65/164 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337029
Domainoid	1	1.000	175	1.000	Domainoid score	I14981
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5182
Inparanoid	1	1.050	496	1.000	Inparanoid score	I6542
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50034
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		oto47794
orthoMCL	1	0.900	-	-		OOG6_117163
Panther	1	1.100	-	-	LDO	PTHR45776
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300