Protein Alignment TFEB and Mitf

DIOPT Version :9

• Sequence 1: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 664
• Identity: 180/664 - (27%)
• Similarity: 251/664 - (37%)
• Gaps: 214/664 - (32%)

Human     5 SGWEPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAV-------MHYM-------------- 48
            ||......||..||..|::||.|||.||    ..:|||.:       ||.:
  Fly   166 SGGPTFKTATPTSRTQLKLQLQREQQQQ----MMIQQQTLDTAMDPKMHLLFGSGQGLMESEFID 226

Human    49 ---------------QQQQQQQQQQLGGPPTPAINTPVHFQS-PPPVPGEVLKVQSYLENPTSYH 97
                           |..|..|...|....:.| ...|..|| ...||.:||:|.:.|||||.||
  Fly   227 SGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGA-KLKVPLQSIGVDVPPQVLQVSTVLENPTRYH 290

Human    98 LQQSQHQKVREYLSETY---------------------------------------GNKF----- 118
            :.|.|..:||:||||::                                       .|:|
  Fly   291 VIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSA 355

Human   119 --AAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRL 181
              |..|.|:..:....|.....||...:.........|||     |....||.........:.:.
  Fly   356 VSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNS-----HGAGEPENAHRTAQLGLSKA 415

Human   182 DDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGV-TSSSCPAD---------------- 229
            :..|........:.|::.:||:..::.|:...::.|:..| ||.|.|.|
  Fly   416 NSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKN 480

Human   230 ----LTQKRE---LTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDL----- 282
                |:.|:|   |||||..||||:||||||||:|||||||||||||||||.|:||.:|.
  Fly   481 FNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVV 545

Human   283 -DVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGL---- 342
             |:|.|||||||:|||||:.::.::.:.|:.|...|::|:.|::|..||:||||||:.||:
  Fly   546 RDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSE 610

Human   343 --------------------PTTSPSGMNMAELAQQVVKQELPSEEGPG------------EALM 375
                                ||.|.|   ...|..|.|::::...:|..            |...
  Fly   611 NHLTSLSAPTQPYLKSFSLSPTASRS---RRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCK 672

Human   376 LGAEVPDP--------EPLPALPPQAPLPLPTQPPSPFHHLDFS--------------------- 411
            ...:..||        :..|..|....|...:..|..|...|.|
  Fly   673 YAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKSSLASDDCCGINCSTS 737

Human   412 ----HSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEA 472
                |.|:    ..||.|.:      .|.:....:..........:.|.|....|||||
  Fly   738 CYIQHQLT----SREGHPNH------SHHTGIREIHSLSDSAQNSEFSRLEHCDDPLLS------ 786

Human   473 SKASSRRSSFSMEE 486
               ||.||..:::|
  Fly   787 ---SSHRSLGTVDE 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..175	CDD:292573	56/239 (23%)
		HLH	247..307	CDD:238036	43/65 (66%)
		DUF3371	335..471	CDD:288684	36/204 (18%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	20/38 (53%)
		HLH	505..570	CDD:238036	43/64 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157591
Domainoid	1	1.000	85	1.000	Domainoid score	I8159
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4199
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm40964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890