Protein Alignment TFEB and Tfeb

DIOPT Version :10

• Sequence 1: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Sequence 2: XP_063123157.1
• Gene: Tfeb / 316214
• RGDID: 1309583
• Length: 485
• Species: Rattus norvegicus
• Alignment Length: 483
• Identity: 452/483 - (93%)
• Similarity: 461/483 - (95%)
• Gaps: 0/483 - (0%)

Human     8 EPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVH 72
            ||...|.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     3 EPESTAAMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVH 67

Human    73 FQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASP 137
            |||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat    68 FQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHVSPAQGSPKPPPAASP 132

Human   138 GVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSS 202
            |||||||||:||||||||||||||||.||||:|.|||||||||||.|||||||||||||||||||
  Rat   133 GVRAGHVLSTSAGNSAPNSPMAMLHISSNPEKEFDDVIDNIMRLDSVLGYINPEMQMPNTLPLSS 197

Human   203 SHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNIND 267
            |||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   198 SHLNVYSGDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNIND 262

Human   268 RIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQE 332
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   263 RIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQE 327

Human   333 LEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPL 397
            |||||||||||||||||:|||||||||||||||||:.|||.||||:|||||||:||||||||||.
  Rat   328 LEMQARVHGLPTTSPSGVNMAELAQQVVKQELPSEDNPGETLMLGSEVPDPEPMPALPPQAPLPS 392

Human   398 PTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASD 462
            ..||.||||||||||.|||||..||||.|||:||...||||||:|||||||||||||||||||||
  Rat   393 AAQPQSPFHHLDFSHGLSFGGGGDEGPAGYPDPLGTEHGSPFPNLSKKDLDLMLLDDSLLPLASD 457

Human   463 PLLSTMSPEASKASSRRSSFSMEEGDVL 490
            ||.|||||||||||||||||||||||||
  Rat   458 PLFSTMSPEASKASSRRSSFSMEEGDVL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..176	CDD:464952	152/157 (97%)
		bHLHzip_TFEB	240..330	CDD:381497	89/89 (100%)
		DUF3371	335..487	CDD:463372	131/151 (87%)
Tfeb	XP_063123157.1	None