Protein Alignment TFEB and Tfeb

DIOPT Version :10

• Sequence 1: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Sequence 2: XP_006524067.1
• Gene: Tfeb / 21425
• MGIID: 103270
• Length: 510
• Species: Mus musculus
• Alignment Length: 492
• Identity: 452/492 - (91%)
• Similarity: 464/492 - (94%)
• Gaps: 5/492 - (1%)

Human     3 ASSGW----EPAPAATMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPP 63
            |:||:    ||.|.|.|||||||||||||||||||||||||||||||||| ||||||||||||||
Mouse    20 AASGYPFHREPEPTAAMASRIGLRMQLMREQAQQEEQRERMQQQAVMHYM-QQQQQQQQQLGGPP 83

Human    64 TPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGS 128
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
Mouse    84 TPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHVSPAQGS 148

Human   129 PKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQ 193
            |||.||||||||||||||:||||||||||||||||.||||:|.|||||||||||.||||||||||
Mouse   149 PKPAPAASPGVRAGHVLSTSAGNSAPNSPMAMLHISSNPEKEFDDVIDNIMRLDSVLGYINPEMQ 213

Human   194 MPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIE 258
            ||||||||||||||||.|||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   214 MPNTLPLSSSHLNVYSGDPQVTASMVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIE 278

Human   259 RRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTN 323
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   279 RRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTN 343

Human   324 KQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPA 388
            ||||||||||||||||||||||||||:|||||||||||||||||:|||||||||.|||:||.:||
Mouse   344 KQLWLRIQELEMQARVHGLPTTSPSGVNMAELAQQVVKQELPSEDGPGEALMLGPEVPEPEQMPA 408

Human   389 LPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLD 453
            ||||||||...||.||||||||||.|||||..||||.|||:.|...||||||:||||||||||||
Mouse   409 LPPQAPLPSAAQPQSPFHHLDFSHGLSFGGGGDEGPTGYPDTLGTEHGSPFPNLSKKDLDLMLLD 473

Human   454 DSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDVL 490
            |||||||||||.|||||||||||||||||||||||||
Mouse   474 DSLLPLASDPLFSTMSPEASKASSRRSSFSMEEGDVL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..176	CDD:464952	150/157 (96%)
		bHLHzip_TFEB	240..330	CDD:381497	89/89 (100%)
		DUF3371	335..487	CDD:463372	130/151 (86%)
Tfeb	XP_006524067.1	MITF_TFEB_C_3_N	39..196	CDD:464952	150/157 (96%)
		bHLHzip_TFEB	260..350	CDD:381497	89/89 (100%)
		DUF3371	355..507	CDD:463372	130/151 (86%)