Protein Alignment TFEB and hlh-30

DIOPT Version :10

• Sequence 1: NP_001161299.2
• Gene: TFEB / 7942
• HGNCID: 11753
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_001023411.1
• Gene: hlh-30 / 177157
• WormBaseID: WBGene00020930
• Length: 524
• Species: Caenorhabditis elegans
• Alignment Length: 544
• Identity: 153/544 - (28%)
• Similarity: 221/544 - (40%)
• Gaps: 152/544 - (27%)

Human    20 GLRMQLMREQ----AQQEEQRERMQQQ----------------AVMHYMQQQQQQ------QQQQ 58
            ||.:...|.|    |||::|.::.|||                .....|:|:::.      .|:.
 Worm    13 GLGLNNPRAQQPPGAQQQQQPQQAQQQFYDDEPYQANASQFRFGAGKSMEQRRETGNLIPIAQRS 77

Human    59 LGGPPTPAINTPVHFQSPPPVPGEVLKVQSY---------LENPTSYHLQQSQHQKVREYLSETY 114
            :|...||       |.|.|        .|||         |.:|..   .|..||.:       :
 Worm    78 MGSTSTP-------FGSAP--------TQSYFGGGSSGAALSSPRK---MQQTHQML-------F 117

Human   115 GNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDD-VIDNI 178
            ||     |.|.:||| |...:....|.|.  |.:.|.           :|.....|||| :||.:
 Worm   118 GN-----IQPPRGSP-PSDGSDKIHRFGE--SPTPGG-----------VGGVFGTELDDLIIDEL 163

Human   179 MRLDDVL----GYINP-------EMQMPNTLPLSSSHLNVYSSDPQVTA------SLVGVTSSSC 226
            |.::|..    |...|       .|.|...:|.:||......|...:|.      :...|.|||.
 Worm   164 MGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSGSPITIPNAMSNNFRQVVSSSA 228

Human   227 PADLTQKRELTDAESRA------------LAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKA 279
            |.......::..|.|..            ..::|:|||.||:||||||:||||||||||.::||.
 Worm   229 PTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDIHNMIERRRRYNINDRIKELGQMLPKN 293

Human   280 NDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQEL-EMQAR--VHG 341
            ...|::.|||||||||.||||.:|||.:::.:.:...:.||.|..:...|::|| ||.||  |..
 Worm   294 TSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQQQQKSLESTAHKYADRVKELEEMLARQGVQV 358

Human   342 LPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQP----P 402
            .|:..|.   :.::.::.:|||:  :|.|......|:.|.....|..:.........|.|    |
 Worm   359 PPSHLPP---IPKVIERPIKQEI--DESPPNHTPTGSFVSSSGFLSEVTNNTAAMQITSPNDSRP 418

Human   403 SPFHHLDFSHSLSFGGREDEGPPGYPEPLA------PGHGSPFPSLSKKDLDLMLLDDSLLPLAS 461
            :.|.: :.:.|.||.......||.|.....      ||        |....|||:  |.|.|:.:
 Worm   419 NNFMN-NSAPSDSFFSVGSASPPDYRTSSGTASWKLPG--------SNAFSDLMM--DDLNPMMN 472

Human   462 -DPLLST-------------MSPE 471
             |||:|:             |||:
 Worm   473 GDPLISSAGAHPSPHFHSSQMSPD 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TFEB	NP_001161299.2	MITF_TFEB_C_3_N	18..176	CDD:464952	45/191 (24%)
		bHLHzip_TFEB	240..330	CDD:381497	45/101 (45%)
		DUF3371	335..487	CDD:463372	40/163 (25%)
hlh-30	NP_001023411.1	bHLHzip_MITF_like	260..328	CDD:381403	41/67 (61%)