DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf13 and HRD1

DIOPT Version :9

Sequence 1:	NP_957338.1	Gene:	rnf13 / 793981	ZFINID:	ZDB-GENE-040426-772	Length:	377	Species:	Danio rerio
Sequence 2:	NP_014630.1	Gene:	HRD1 / 854149	SGDID:	S000005373	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	470	Identity:	105/470 - (22%)
Similarity:	173/470 - (36%)	Gaps:	135/470 - (28%)

- Green bases have known domain annotations that are detailed below.

Zfish    10 LSATQIYTIFTVQIF--------AFLNLLPVEADISAYSFDNKTE----NFDD-------LPARF 55
            |..|.|.|:|...:|        ||..||.:...:..:...::.|    :.:|       :.:||
Yeast    86 LPFTIINTLFMSSLFHERYFFTVAFFGLLLLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRF 150

Zfish    56 GYRLPSEGLKGFLIGARPENACVPIEPPPQRENLSSAFIVLIRRFDCN---FDIKVLHAQKA--- 114
            .:.|....:..:.|..|    |:......|:.::.|..:.||:..:..   .|:..|..|..
Yeast   151 SFNLVLLAVVDYQIITR----CISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNF 211

Zfish   115 --GYKAA---------IVH-------NVDSDDLISMGSEDLDILKQIDIPSVFIGEEAANSLKED 161
              .|::.         |||       .|:||....:.::|.|   ..|....|.|      |:..
Yeast   212 WEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDD---DDDDDRQFTG------LEGK 267

Zfish   162 YIYEKGGHV---ILMPDFSLPLEYYLIPFLIIVGICLILIVVFMITKFVQDRHRA----RRSRLR 219
            ::|||...|   .|.....|.:   ||||.  :.:.|:..||:.|....|.....    |.::..
Yeast   268 FMYEKAIDVFTRFLKTALHLSM---LIPFR--MPMMLLKDVVWDILALYQSGTSLWKIWRNNKQL 327

Zfish   220 KDQLKKLPIHKFKKGDSYD-VCAICLDEY----------EEGERLRVLPCSHAYHCKCVDPWLTK 273
            .|.|..:.:.:.:...:.| :|.||:||.          .:.::.:.|||.|..|..|:..|:.:
Yeast   328 DDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRLPCGHILHLSCLKNWMER 392

Zfish   274 TKKTCPVCKQKVVPSDGD-------SESD-------SDS----VDSGGEDNEVS-----ENTPLL 315
            : :|||:|:..|....|:       |.||       :||    .|..|..|||.     ..:|.:
Yeast   393 S-QTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDI 456

Zfish   316 R--------SLA----STSA----------HSFGSMSASLSQHDAGSSDYDERSDSSDSEE---- 354
            |        :||    |||.          |..|..|...|:     |.|:....:||.:|
Yeast   457 RIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSR-----SAYEFLITNSDEKENGIP 516

Zfish   355 -EVTVETVVVQLQQG 368
             ::|:|...|....|
Yeast   517 VKLTIENHEVNSLHG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf13	NP_957338.1	PA_C_RZF_like	23..180	CDD:239038	39/202 (19%)
rnf13	NP_957338.1	zf-RING_2	238..282	CDD:290367	16/54 (30%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	105/470 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910