DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCRL2 and Fcrls

DIOPT Version :9

Sequence 1:	XP_016857805.1	Gene:	FCRL2 / 79368	HGNCID:	14875	Length:	523	Species:	Homo sapiens
Sequence 2:	NP_109632.2	Gene:	Fcrls / 80891	MGIID:	1933397	Length:	509	Species:	Mus musculus

Alignment Length:	498	Identity:	205/498 - (41%)
Similarity:	278/498 - (55%)	Gaps:	60/498 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLWSLLVIFDAVTEQADSLTLVAPSSVFEGDSIVLKCQGEQNWKIQKMAYHKDNKELSVFKKFS 65
            |.|..||::|..|..|:|.|::..|...:|||.:|:.|.|:.|..|:::.|.||...:..:...|
Mouse     1 MPLCLLLLVFAPVGVQSDWLSISLPHRSYEGDQVVISCTGKNNGDIKRLKYFKDGYHIETYSSAS 65

Human    66 DFLIQSAVLSDSGNYFCSTKGQLFLWDKTSNIVKIK---VQELFQRPVLTASSFQPIEGGPVSLK 127
            .:.|::|...|||:|.|....:.||:..|:.....|   |||||..|.||||..||:||..|:|.
Mouse    66 SYTIRNARRGDSGSYSCKADRKFFLFIDTTEETGSKWLNVQELFPAPGLTASPLQPVEGSSVTLS 130

Human   128 CETRLSPQRLDVQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQ 192
            |.|.|...|...||::.||::...|.|||:|| :..|||:..||:|:|||:|.|.:..:.|||.:
Mouse   131 CNTWLPSDRATTQLRYSFFKDGHTLQSGWTSS-KFTISAISKEDSGNYWCEAMTASRSVSKQSHR 194

Human   193 SQIHVQRIPISNVSLEIRAPGG-------QVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGK 250
            |.|.|:|||:|.|::||:...|       .|.||:.|:|.||||.|||.:||||:|:.|..|:||
Mouse   195 SYIDVERIPVSQVTMEIQPSRGWGVEGEPLVVEGEPLVLACSVAKGTGLITFSWHRQDTKESVGK 259

Human   251 KTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGD 315
            |:|||...|||||.::||.||.|||.|||.:..|||.:|||.|:|||..|:|::..||....:||
Mouse   260 KSQRSQRVELEIPTIRESHAGGYYCTADNNYGLIQSAIVNITVKIPVLNPLLSISVPGVLPFIGD 324

Human   316 LLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSE 380
            :.|||||..|.|||:||.||||::||.|:|||.||.|||.|||||.|||||||||.|..|.:.||
Mouse   325 VAELHCEDKRASPPVLYWFYHENITLANTSAPFGGKASFKLSLTAGHSGNYSCEAENAWGTKRSE 389

Human   381 AVPVSISGPDGYRRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGESSATNEPR--------- 436
            .|.::::.|....|  :..|.                     |...|......|.|
Mouse   390 VVTLNVTEPPPKVR--LVNGP---------------------HHCEGRVEVEQEGRWGTVCDDGW 431

Human   437 --------------GASRPNPQEFTYSSPTPDMEELQPVYVNV 465
                          ||::..|....|   .|.::|..||.:.|
Mouse   432 DMRDVAVVCRELGCGAAQHTPIAMLY---PPAVDEALPVLIQV 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL2	XP_016857805.1	None
Fcrls	NP_109632.2	Ig	19..85	CDD:386229	21/65 (32%)
		Ig_3	112..181	CDD:372822	34/69 (49%)
		IG_like	224..302	CDD:214653	46/77 (60%)
		IG	316..395	CDD:214652	49/78 (63%)
		SR	402..502	CDD:214555	15/96 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2DMWR
HGNC	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I14189
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208751at32523
OrthoFinder	1	1.000	-	-		FOG0005273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X79
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.830