DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCRL2 and side-VI

DIOPT Version :9

Sequence 1:	XP_016857805.1	Gene:	FCRL2 / 79368	HGNCID:	14875	Length:	523	Species:	Homo sapiens
Sequence 2:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	95/454 - (20%)
Similarity:	150/454 - (33%)	Gaps:	124/454 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   113 ASSFQP-------IEGGPVSLKCETRLSPQRLDVQLQFCFFRENQVL------------GSGW-- 156
            |..|:|       :......:||:.. |.|..|..|...:::.|..:            .|.|
  Fly    25 ADGFKPDGEILRVLVNSSAQIKCDVG-SSQADDKVLLVVWYKNNLPIYSYDTRGAHAGTPSHWRD 88

Human   157 -------------SSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHV---QRIPISNV 205
                         ....||.|:.|..:|.|::.|:.:....:.|..::..::.|   |.|..:..
  Fly    89 EEVLEDRAVFRTHKEPAELIINPVKEKDAGNFRCRVDFKLSQTRNSNVNLEVVVPPTQPIIFNER 153

Human   206 SLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREA-----------TGTSMGKKTQRSLSAE 259
            .|.|.:..|...||..|.:.|.|.||:...|..|....           .|....|...|:|| .
  Fly   154 RLRIDSRAGPYEEGGSLEVTCVVYGGSPPPTVIWLMNGQLQNSVVDYTYDGAINSKLVVRNLS-R 217

Human   260 LEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGD-LLELHCEA 323
            :...||       |.|:|.|.|....:..:.|.:.:   ||:|...|...|....| ..|:.|:|
  Fly   218 IHQHAV-------YTCQASNFHKKYVATNITIDLYL---RPLLVEISFNNQPMSADRKYEIECQA 272

Human   324 LRGSPPILYQFYHEDVTL-GNSSAPS--GGGASFNLSLT---AEHSGNYSCEANNGLGAQCSEAV 382
            :...||....::..::.| |:|...|  |..::..||:|   .:|....||.|.|.|..
  Fly   273 IGSRPPAKITWWMGNLELHGHSQKVSEDGNVSTSVLSITPTREDHGKALSCRATNELVR------ 331

Human   383 PVSISGPDGYRRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGESSATNEPRGASRPNPQEFT 447
                   :|.|...|...|.:          :..|...|                .|..||:
  Fly   332 -------NGIRETAMKLNVFF----------IPTLQLDL----------------GSNLNPE--- 360

Human   448 YSSPTPDMEELQPVYVNVGSVDVDVVYSQVWS-----MQQPESSGLPSHLLFCEEIITLGGIRR 506
                  |:||...||...........|..||.     :|..:.:|    ::.....:.|.|:.|
  Fly   361 ------DIEEGDDVYFECKVHANPAAYKVVWKHNHQIIQHNQRAG----VIVSSGDLALQGVTR 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL2	XP_016857805.1	None
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	17/105 (16%)
		Ig_3	157..230	CDD:290638	21/80 (26%)
		IG_like	165..242	CDD:214653	21/84 (25%)
		Ig	265..343	CDD:299845	22/90 (24%)
		IG_like	267..343	CDD:214653	22/88 (25%)
		IG_like	363..440	CDD:214653	12/56 (21%)
		IGc2	364..429	CDD:197706	11/55 (20%)
		IG_like	456..532	CDD:214653
		Ig_3	456..524	CDD:290638
		fn3	545..622	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910