DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FCRL2 and Fcrl5

DIOPT Version :9

Sequence 1:	XP_016857805.1	Gene:	FCRL2 / 79368	HGNCID:	14875	Length:	523	Species:	Homo sapiens
Sequence 2:	NP_899045.3	Gene:	Fcrl5 / 329693	MGIID:	3053558	Length:	596	Species:	Mus musculus

Alignment Length:	476	Identity:	213/476 - (44%)
Similarity:	292/476 - (61%)	Gaps:	39/476 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    18 DSLTLVAPSSVFEGDSIVLKCQGEQNWKIQKMAYHKDNKELSVFKKFSDFLIQSAVLSDSGNYFC 82
            |.|.|.||.:||||||:||:|..::..:.:.:.::||.|.|::..:.|:|.|..|.|.|:|.|.|
Mouse   117 DFLVLQAPPAVFEGDSVVLRCYAKKGIEAETLTFYKDGKALTLHPQSSEFYIHRANLKDNGQYKC 181

Human    83 STK-----GQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPIEGGPVSLKCETRLSPQRLDVQLQ 142
            ::|     |.|:    |||.|.::|||||.||||.|....||:|.||:|.|:|:||.|:.|.:||
Mouse   182 TSKKKWSFGSLY----TSNTVVVQVQELFPRPVLRARPSHPIDGSPVTLTCQTQLSAQKSDARLQ 242

Human   143 FCFFRENQVLGSGWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQR-------- 199
            |||||..|:||||.|.|.|..|.|:|:|::..|.||||||..::.|||....|.|||
Mouse   243 FCFFRNLQLLGSGCSRSSEFHIPAIWTEESKRYQCKAETVNSQVSKQSTAFIIPVQRASARFQTH 307

Human   200 -IPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQ--RSLSAELE 261
             ||.|.:          |.|||.|:|.|||.|..|.:.||||::   ..:.|:|:  :|.:||.:
Mouse   308 IIPASKL----------VFEGQLLLLNCSVKGVPGPLKFSWYKK---DMLNKETKILKSSNAEFK 359

Human   262 IPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLELHCEALRG 326
            |..|..||||:|||.|:|......|:...|.:::|||:|||||.:...||..|||:.|||::.||
Mouse   360 ISQVNISDAGEYYCEANNSRRSFVSRAFPITIKVPVSQPVLTLSTGKTQALEGDLMTLHCQSQRG 424

Human   327 SPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSEAVPVSISGPDG 391
            ||.|||:|::|:|:|||||..|||||.||.|::.|.||||.|.|:||||||||||:.:||.....
Mouse   425 SPCILYEFFYENVSLGNSSILSGGGAYFNFSMSTERSGNYYCTADNGLGAQCSEAIRISIFDMTK 489

Human   392 YRRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGESSATNEPRGASRPNPQEFTYSSPTPDME 456
            .|...|.||:..||  ::...|| .|.|..|.:.:|....:::.|..|...|||.||.: .|...
Mouse   490 NRSVPMAAGITVGL--LIMAVGV-FLFYCWFSRKAGGKPTSDDSRNPSDSEPQEPTYYN-VPACI 550

Human   457 ELQPVYVNVGSVDVDVVYSQV 477
            ||||||.|  ..:.:|:|::|
Mouse   551 ELQPVYSN--EPEENVIYTEV 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL2	XP_016857805.1	None
Fcrl5	NP_899045.3	Ig	34..112	CDD:299845
		IG_like	40..101	CDD:214653
		Ig	119..202	CDD:299845	33/86 (38%)
		IG_like	127..200	CDD:214653	29/76 (38%)
		Ig_2	209..297	CDD:290606	46/87 (53%)
		Ig_2	308..391	CDD:290606	36/95 (38%)
		IG_like	310..393	CDD:214653	35/95 (37%)
		Ig_2	398..484	CDD:290606	53/85 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..544		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..596		3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I45555
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG36261
OrthoDB	1	1.010	-	-		D208751at32523
OrthoFinder	1	1.000	-	-		FOG0005273
OrthoInspector	1	1.000	-	-		otm51797
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X79
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930