DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BHLHE41 and cwo

DIOPT Version :9

Sequence 1:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	441	Identity:	99/441 - (22%)
Similarity:	155/441 - (35%)	Gaps:	137/441 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    37 KRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTA 101
            :|:.|.....|.||:|||:||||:|.|:|.|..|:|...:....|.:||..::|:.::|||.|.:
  Fly    55 RRNKTSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQS 119

Human   102 LTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHL 166
            ..:|:                  :||   :.||:..|.||..::|....    .:..|.:|:..|
  Fly   120 ECQQK------------------ESD---YRSGYMDCMKEAAKFLYDVH----MQDFCHRLLGRL 159

Human   167 HAVATQFLPT---PQLLTQQVP--LSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQP 226
            .....:...|   ....:..:|  :|..:|:|..|..             .||.:...::..:..
  Fly   160 QEHIDEMFKTDCYKSTRSCHMPDNVSASSGSPHQAYH-------------PPLCHLRDMLATSAS 211

Human   227 SAELAAENDTDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGG 291
            ..|.:.:::...|..:..........::...|.|.
  Fly   212 DVEHSQDHNDVKDLSFRNHLNQLQRSQQAAAAAAV------------------------------ 246

Human   292 GPGGGAAAAAAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSP 356
                 ||||.|...|..||:.|.:   |:.:  .|...||.||||   |||...|        |.
  Fly   247 -----AAAAVAVANGSSPASNAGV---DSKV--PLTNGGGTGGAP---PAADNVP--------SN 290

Human   357 SAAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLSP 421
            |..:                                 ..|||.|...:.::.:.:....||.:.|
  Fly   291 STGS---------------------------------GSAAACAGGNSNSSGSNSSNAASSTICP 322

Human   422 P-----PEKAGAAAATLLPHEVAPL---GAPHPQHPH-GRTHLPFAGPREP 463
            |     |.|....||...||: ||:   .|||..|.| ..:|..|...|||
  Fly   323 PAGGSCPAKVTPLAAHQQPHQ-APVITSTAPHHHHHHTDSSHHDFESSREP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	27/84 (32%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		1/3 (33%)
		ORANGE	129..175	CDD:128787	9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298		4/69 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482		12/30 (40%)
cwo	NP_524775.1	HLH	66..118	CDD:306515	22/51 (43%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	11/48 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740