DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHE41 and E(spl)m7-HLH

DIOPT Version :9

Sequence 1:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster

Alignment Length:	204	Identity:	54/204 - (26%)
Similarity:	93/204 - (45%)	Gaps:	52/204 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    44 TY---KLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQ 105
            ||   |:...|:|:|||.|||:|:.:||||:.|.:..|.....|||.:||:|::||:.|     :
  Fly    10 TYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGDAKFEKADILEVTVQHLRKL-----K 69

Human   106 QHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRC-----VQLINH 165
            :.:|.:.        .:|.||    |.:|:...|.||.:.|:..       ||.     ..|:.|
  Fly    70 ESKKHVP--------ANPEQS----FRAGYIRAANEVSRALASL-------PRVDVAFGTTLMTH 115

Human   166 LHAVATQF---LPTPQLLTQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPS 227
            |.....|.   :..||.:...:.:..|:.:.|:..|:|:.|     ..:.|:            |
  Fly   116 LGMRLNQLEQPMEQPQAVNTPLSIVCGSSSSSSTYSSASSC-----SSISPV------------S 163

Human   228 AELAAENDT 236
            :..|::|::
  Fly   164 SGYASDNES 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	28/80 (35%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		3/3 (100%)
		ORANGE	129..175	CDD:128787	12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	25/64 (39%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	14/54 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140899
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840