DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHE41 and E(spl)m5-HLH

DIOPT Version :9

Sequence 1:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster

Alignment Length:	174	Identity:	40/174 - (22%)
Similarity:	77/174 - (44%)	Gaps:	33/174 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    41 TKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQ 105
            |:...|:...|:|::||.|:|:|:..||.|:.|......:..::||.:||..|..::
  Fly    15 TQHYLKVKKPLLERQRRARMNKCLDTLKTLVAEFQGDDAILRMDKAEMLEAALVFMR-------- 71

Human   106 QHQKIIALQNGERSLKSPIQS-DLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCV--QLINHLH 167
              ::::..|       :|:.. .:|:|.:|:.....|:    ||..:.||.....|  .::.||.
  Fly    72 --KQVVKQQ-------APVSPLPMDSFKNGYMNAVSEI----SRVMACTPAMSVDVGKTVMTHLG 123

Human   168 AVATQFLPTPQLLTQQVPLSKGTGAPSAAG---------SAAAP 202
            ....:.|...|:.|.....:....:|:::|         |||:|
  Fly   124 VEFQRMLQADQVQTSVTTSTPRPLSPASSGYHSDNEDSQSAASP 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	19/80 (24%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		2/3 (67%)
		ORANGE	129..175	CDD:128787	11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	17/61 (28%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840