DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHE41 and E(spl)m3-HLH

DIOPT Version :9

Sequence 1:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster

Alignment Length:	184	Identity:	57/184 - (30%)
Similarity:	88/184 - (47%)	Gaps:	27/184 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    36 MKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKL--TTLGHLEKAVVLELTLKHLKA 98
            |:...|....|:...|:|:|||.|||:|:..||||:.|.|:.  ..:..||||.:||||:.|::.
  Fly     3 MEMSKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRK 67

Human    99 LTALTEQQHQKIIALQNGERSLKSPIQS----DLDAFHSGFQTCAKEVLQYLSRFESWTPREPRC 159
            |      :.:..::||.....:.||..|    .:::|.||:...|.::.|.|.:.:. |....|.
  Fly    68 L------KQRGGLSLQGVVAGVGSPPTSTSTAHVESFRSGYVHAADQITQVLLQTQQ-TDEIGRK 125

Human   160 VQ--LINHLHAVATQFLPTPQL----LTQQVPLSKGTGA--------PSAAGSA 199
            :.  |...|..:.||.|...|.    ..||:|.|.|..|        |:||.:|
  Fly   126 IMKFLSTRLIELQTQLLQQQQQQQQHQQQQIPQSSGRLAFPLLGGYGPAAAAAA 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	30/87 (34%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		3/3 (100%)
		ORANGE	129..175	CDD:128787	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	26/64 (41%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	10/40 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140893
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840