DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHE41 and E(spl)mbeta-HLH

DIOPT Version :9

Sequence 1:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_524505.2	Gene:	E(spl)mbeta-HLH / 43152	FlyBaseID:	FBgn0002733	Length:	195	Species:	Drosophila melanogaster

Alignment Length:	198	Identity:	58/198 - (29%)
Similarity:	90/198 - (45%)	Gaps:	43/198 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    36 MKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLG----HLEKAVVLELTLKHL 96
            |:...|....|:...::|:|||.|||:|:.:|||::.|  .||..|    .||||.:||||::|:
  Fly     5 MEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVE--CLTQEGEHITRLEKADILELTVEHM 67

Human    97 KALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRC-- 159
            |.|.|   |:..::.::..|......|..|..::|.:|:...|.||.:.|:..       |..
  Fly    68 KKLRA---QKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAV-------PGVSV 122

Human   160 ---VQLINHL-HAVATQFLPTPQL---LTQQVP----------------LSKG--TGAPSAAGSA 199
               .||::|| |.:....:..|.|   :..|.|                |..|  :.|||.|.|.
  Fly   123 DLGTQLMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASST 187

Human   200 AAP 202
            :.|
  Fly   188 SGP 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	32/89 (36%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		3/3 (100%)
		ORANGE	129..175	CDD:128787	12/51 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482
E(spl)mbeta-HLH	NP_524505.2	HLH	13..75	CDD:238036	29/66 (44%)
E(spl)mbeta-HLH	NP_524505.2	ORANGE	97..141	CDD:128787	12/50 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140892
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840