DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BHLHE41 and E(spl)mgamma-HLH

DIOPT Version :9

Sequence 1:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster

Alignment Length:	196	Identity:	52/196 - (26%)
Similarity:	90/196 - (45%)	Gaps:	42/196 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    35 SMKRDDTKDTY---KLPHRLIEKKRRDRINECIAQLKDLL-------PEHLKLTTLGHLEKAVVL 89
            |::..:...||   |:...::|:|||.|||:|:.:||||:       .||:.     .||||.:|
  Fly     3 SLQMSEMSKTYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVT-----RLEKADIL 62

Human    90 ELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESW-- 152
            |||:.||:.:.  .::||::    .:|:.||     :..:.|.||:.....||.:.||:....
  Fly    63 ELTVTHLQKMK--QQRQHKR----ASGDESL-----TPAEGFRSGYIHAVNEVSRSLSQLPGMNV 116

Human   153 ---TPREPRCVQLINHLHAVATQFLPTPQLLTQQV-----------PLSKGTGAPSAAGSAAAPC 203
               |.......|.:|.:.....:.||....|:..:           |:|...|:|::..|:.:..
  Fly   117 SLGTQLMTHLGQRLNQIQPAEKEVLPVTAPLSVHIANRDAYSVPISPISSYAGSPNSNTSSTSHS 181

Human   204 L 204
            |
  Fly   182 L 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	33/96 (34%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		3/3 (100%)
		ORANGE	129..175	CDD:128787	10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	25/68 (37%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840