DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHE41 and dpn

DIOPT Version :9

Sequence 1:	NP_110389.1	Gene:	BHLHE41 / 79365	HGNCID:	16617	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	99/467 - (21%)
Similarity:	158/467 - (33%)	Gaps:	165/467 - (35%)

- Green bases have known domain annotations that are detailed below.

Human    14 LEHRDFIGLD--------YSSLY-----MCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRINECIA 65
            :::::.|..|        ||..|     |..| ..:.:.:.:.|.|   .::||:||.|||.|:.
  Fly     1 MDYKNDINSDDDFDCSNGYSDSYGSNGRMSNP-NGLSKAELRKTNK---PIMEKRRRARINHCLN 61

Human    66 QLKDLLPEHLKLTTLGH--LEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPIQSD- 127
            :||.|:.|.:|.....|  ||||.:||:|:|||:::      |.|:          |...||||
  Fly    62 ELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSV------QRQQ----------LNMAIQSDP 110

Human   128 --LDAFHSGFQTCAKEVLQYLSRFES--------WTPREPRCVQLINHL---------------H 167
              :..|.:||..||:||.:|:|:.:.        .:....:|...:..:               .
  Fly   111 SVVQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGLFP 175

Human   168 AVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAA 232
            |.|....|||...:....|:..:...|     :||.::..|.:|.|         ...||.|.|
  Fly   176 ATAVTAAPTPLFPSLPQDLNNNSRTES-----SAPAIQMGGLQLIP---------SRLPSGEFA- 225

Human   233 ENDTDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGA 297
                                            :.....|..:|.|          |....||..|
  Fly   226 --------------------------------LIMPNTGSAAPPP----------GPFAWPGSAA 248

Human   298 AAAAAALLGPDPAAAAALLRP----DAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSA 358
            ..||    |...||.|::..|    |......:.||.        :|...:.|..||
  Fly   249 GVAA----GTASAALASIANPTHLNDYTQSFRMSAFS--------KPVNTSVPANLP-------- 293

Human   359 AAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCL-------- 415
                          |..::........|:.....|..:..::.::....:.||.|.:
  Fly   294 --------------ENLIHTLPGQTQLPVKNSTSPPLSPISSISSHCEESRAASPTVDVMSKHSF 344

Human   416 SSVLS-PPPEKA 426
            :.|.| |||..|
  Fly   345 AGVFSTPPPTSA 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	30/92 (33%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269\|PubMed:19786558	67..71		2/3 (67%)
		ORANGE	129..175	CDD:128787	12/68 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..298		8/69 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..482
dpn	NP_476923.1	HLH	39..101	CDD:238036	27/70 (39%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910