Protein Alignment BHLHE41 and Sidpn

DIOPT Version :9

• Sequence 1: NP_110389.1
• Gene: BHLHE41 / 79365
• HGNCID: 16617
• Length: 482
• Species: Homo sapiens
• Sequence 2: NP_523599.1
• Gene: Sidpn / 35168
• FlyBaseID: FBgn0032741
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 114/502 - (22%)
• Similarity: 180/502 - (35%)
• Gaps: 131/502 - (26%)

Human    38 RDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGH---------LEKAVVLELTL 93
            :|.:|.|.|   .|:||:||.|||:.:|.||.|:.|..|.....:         ||||.:||||:
  Fly    47 QDISKRTNK---PLMEKRRRARINQSLAILKALILESTKTQNAKNGEGQAKHTKLEKADILELTV 108

Human    94 KHLKALTALTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPR 158
            :|.        |:|          |:|..|   .::.:.:|:..||:||.:||:     ||..|.
  Fly   109 RHF--------QRH----------RNLDDP---TVNKYRAGYTDCAREVARYLA-----TPEPPP 147

Human   159 C------------VQLINHLHAVATQFLPTPQLLTQQVPLSKGTGAPSAAGSAAAPC-------- 203
            .            .:|:.||.....:.         .|.:...:.|..|...:::.|
  Fly   148 MGTMPTLAEPGSKARLLRHLDQCIAEI---------DVEICPHSTAAFAESPSSSSCFDLNHGKK 203

Human   204 -------LERAGQKLEPLAY-----CVPVIQRTQPSAELAAENDTDTDSGYGGEAEAR-PDREKG 255
                   |:.:.|...|:.|     .|...|||.|..  .|..|.:.:.|...:|:.. |.:.:.
  Fly   204 SQPEEHSLDYSSQDSNPVDYSKGLKMVAAEQRTLPVT--PAPQDENNNRGLQAQAQTPIPIQVQS 266

Human   256 KGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAAALL-------------GP 307
            :..|       |..|..|:.||..:..:.           ......|.:|             .|
  Fly   267 QTQG-------QTSPHVDAVAPSELSYEE-----------DRNKVCANVLEQYKQQLKAHVQQQP 313

Human   308 DPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPF--CLPFCFLSPSAAAAYVQPFLDKS 370
            :.|....:|.|....|::.:   |....|...|.|....|  .:....:.|..|......|  ..
  Fly   314 ESANGVLVLPPHYVQLAAAL---GLSAQPLVDPIATRTDFERLIELQRVQPHLAGKLSPSF--PG 373

Human   371 GLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAA-AAAAAAFPCLSSVLSPPPEKAGAAAATLL 434
            |||.....|||||     |....|.||:|.|:.|| |.:.|..|.:..  ..|...|.:.::.:.
  Fly   374 GLEAAHVAAAAAA-----YANSMAVAASAGASVAAMATSGAGTPTVHQ--ERPASVAASVSSGVS 431

Human   435 PHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKEA 481
            ..|:..:.|.....|...:.:   |..|...|.:|.:...|...::|
  Fly   432 MSELKSMPATQQSSPRSESGI---GSNENEAPATSPRPQTSNAARQA 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	31/92 (34%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269|PubMed:19786558	67..71		2/3 (67%)
		ORANGE	129..175	CDD:128787	13/57 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..298		11/70 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..482		8/44 (18%)
Sidpn	NP_523599.1	HLH	48..117	CDD:238036	30/89 (34%)
		Hairy_orange	125..172	CDD:284859	13/51 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910