DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZXDC and ref-2

DIOPT Version :9

Sequence 1:	NP_079388.3	Gene:	ZXDC / 79364	HGNCID:	28160	Length:	858	Species:	Homo sapiens
Sequence 2:	NP_001024478.1	Gene:	ref-2 / 183539	WormBaseID:	WBGene00004335	Length:	315	Species:	Caenorhabditis elegans

Alignment Length:	237	Identity:	58/237 - (24%)
Similarity:	90/237 - (37%)	Gaps:	66/237 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   271 EVCAERFPTHAKLSSH-QRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQELFSCSFPG 334
            :||........:||:| ..:|...:..:.|.:.||::.|
Worm    92 QVCMHVCQNSGELSTHISSNHITHDSKFVCLWKGCDREF-------------------------- 130

Human   335 CSKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHRRKHDDDRRFTCPVEGCGKSF 399
              |.:....:|..|:|.|||||||:||.                                |.|.|
Worm   131 --KMFKAKYKLVNHMRVHTGERPFLCDV--------------------------------CNKVF 161

Human   400 TRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKHVQDVGAPKSRCPVSTCNRLFTS 464
            .|:|:||.|...|.|.|||:|...||...|:..|....|  .||.....|.| |....|.:.:|.
Worm   162 ARSENLKIHKRIHSGEKPFQCTHNGCTKLFANSSDRKKH--MHVHSSHKPYS-CMYPDCGKTYTH 223

Human   465 KHSMKAH-MVRQHSRRQDLLPQLEAPSSLTPSSELSSPGQSE 505
            ..|::.| .|.::.::..|.|:.: .||.:.::.:.:|...|
Worm   224 PSSLRKHTKVHENEKKSQLSPEHD-ESSDSGNASIGTPTTDE 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZXDC	NP_079388.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..174
		C2H2 Zn finger	177..199	CDD:275368
		zf-C2H2_aberr	208..353	CDD:293622	14/82 (17%)
		zf-C2H2	208..232	CDD:278523
		C2H2 Zn finger	210..232	CDD:275368
		C2H2 Zn finger	240..262	CDD:275368
		C2H2 Zn finger	270..290	CDD:275368	5/19 (26%)
		COG5048	<284..443	CDD:227381	39/159 (25%)
		C2H2 Zn finger	299..321	CDD:275368	4/21 (19%)
		C2H2 Zn finger	333..352	CDD:275368	4/18 (22%)
		C2H2 Zn finger	360..382	CDD:275368	2/21 (10%)
		zf-H2C2_2	375..401	CDD:290200	3/25 (12%)
		C2H2 Zn finger	390..412	CDD:275368	8/21 (38%)
		COG5048	391..>584	CDD:227381	35/116 (30%)
		C2H2 Zn finger	420..442	CDD:275368	6/21 (29%)
		Required for transcriptional activation	579..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..756
		Interaction with CIITA	781..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..858
ref-2	NP_001024478.1	zf-H2C2_2	139..163	CDD:290200	15/55 (27%)
		COG5048	150..>227	CDD:227381	31/111 (28%)
		C2H2 Zn finger	154..174	CDD:275368	10/51 (20%)
		zf-H2C2_2	166..193	CDD:290200	12/26 (46%)
		C2H2 Zn finger	182..204	CDD:275368	7/23 (30%)
		C2H2 Zn finger	212..234	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161465654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840