DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf150b and Rnf150

DIOPT Version :9

Sequence 1:	NP_001017554.1	Gene:	rnf150b / 792211	ZFINID:	ZDB-GENE-050417-470	Length:	419	Species:	Danio rerio
Sequence 2:	NP_001178022.1	Gene:	Rnf150 / 364983	RGDID:	1304572	Length:	437	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	296/430 - (68%)
Similarity:	346/430 - (80%)	Gaps:	16/430 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish     1 MALSVIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYVDPDT----------AE 55
            |.:|:|||||||||||||||||||||||||||||||||||||||||||.:|::          ||
  Rat     1 MTMSLIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYTEPESGAAVAGGGGGAE 65

Zfish    56 VRTEKTECGRYGEHSLKREARGVLAMPAAPHDRHACDPSGRFTPRAHGA-WIALISRGNCTYKDK 119
            :.|||:|||||||||.|::|||.:.|.::.|||.||||:.:|...|||. |||||.:|||||:||
  Rat    66 LHTEKSECGRYGEHSPKQDARGEVVMASSVHDRLACDPNTKFAAPAHGKHWIALIPKGNCTYRDK 130

Zfish   120 IRHAVGHNASAVVIFNVGSSNPNETITMPHQGISDVVAIMIPEPKGRELVLLMERNITVHMHITI 184
            ||:|...||||||||||| ||.||||||||.|:.|:||||||||||:|||.|:|||:||.|:|||
  Rat   131 IRNAFLQNASAVVIFNVG-SNTNETITMPHAGVEDIVAIMIPEPKGKELVSLLERNVTVTMYITI 194

Zfish   185 GTRNLQKYVSRTSVVFVSISFIILMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAISQLQ 249
            ||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||:||
  Rat   195 GTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAISKLQ 259

Zfish   250 VRTIRKGDQETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKCCVDPWLVDHRTCPMCKMNILKA 314
            ||||||||:||||||||||||||||||:||||||||||||||.||||||:|||||||||||||||
  Rat   260 VRTIRKGDKETESDFDNCAVCIEGYKPSDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKA 324

Zfish   315 LGLTSSAECLNELPLDYELAVGGVALNAMVMSDDVMAGDVGGARDPGVRMGGLPQVLLDSEPLSQ 379
            ||:..:|:|:::||:|:|.::||...|.:..:.|....:.....||.||..|..||:.|.:|..|
  Rat   325 LGIPPNADCMDDLPIDFEGSLGGPPTNQITGASDTTVNESSVTLDPAVRTVGALQVVQDPDPAPQ 389

Zfish   380 --DTMPTEQSELQPIASGSSDVSLTTG--AGHSDIDTPTD 415
              :.:.|..|:.:|..|..||:||...  .|.||::..||
  Rat   390 EGEAIFTTNSDQEPAVSSDSDISLIMALEVGLSDVELSTD 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf150b	NP_001017554.1	PA_GRAIL_like	45..182	CDD:239037	93/147 (63%)
		UPF0233	<196..>221	CDD:299753	23/24 (96%)
		zf-RING_2	265..308	CDD:290367	39/42 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..419		15/46 (33%)
Rnf150	NP_001178022.1	PA_GRAIL_like	45..192	CDD:239037	93/147 (63%)
		UPF0233	<206..>231	CDD:299753	23/24 (96%)
		zf-RING_2	275..318	CDD:290367	39/42 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194889816
Domainoid	1	1.000	102	1.000	Domainoid score	I24293
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	590	1.000	Inparanoid score	I5108
OMA	1	1.010	-	-		QHG50669
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto62707
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.770