DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf150b and H10E21.5

DIOPT Version :9

Sequence 1:	NP_001017554.1	Gene:	rnf150b / 792211	ZFINID:	ZDB-GENE-050417-470	Length:	419	Species:	Danio rerio
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	156	Identity:	84/156 - (53%)
Similarity:	116/156 - (74%)	Gaps:	15/156 - (9%)

- Green bases have known domain annotations that are detailed below.

Zfish   194 SRTSVVFVSISFIILMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAISQLQVRTIRKG-D 257
            |:|||:||||||||||:||||||||||:||||||:|:||.||||.:||:||::::...||..| .
Worm   156 SKTSVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPGMT 220

Zfish   258 QETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKCCVDPWLVDHRTCPMCKMNILKALGLTSSAE 322
            ||.:||   ||||::.|:..||:|:|||:|::||.|:||||::||||||||.:|||..|.
Worm   221 QELQSD---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGY----- 277

Zfish   323 CLNELPLDYELAVGGVALNAMVMSDD 348
             .|::..|.::..     |:..::||
Worm   278 -WNDIRNDIQMPT-----NSRGIADD 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf150b	NP_001017554.1	PA_GRAIL_like	45..182	CDD:239037
		UPF0233	<196..>221	CDD:299753	22/24 (92%)
		zf-RING_2	265..308	CDD:290367	25/42 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..419
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	84/156 (54%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	29/49 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161007949
Domainoid	1	1.000	82	1.000	Domainoid score	I5903
eggNOG	1	0.900	-	-		E33208_3BHU7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm12529
orthoMCL	1	0.900	-	-		OOG6_107948
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730