DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SLC39A7 and Catsup

DIOPT Version :9

Sequence 1:	NP_001070984.1	Gene:	SLC39A7 / 7922	HGNCID:	4927	Length:	469	Species:	Homo sapiens
Sequence 2:	NP_524931.1	Gene:	Catsup / 48805	FlyBaseID:	FBgn0002022	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	227/447 - (50%)
Similarity:	287/447 - (64%)	Gaps:	70/447 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    48 RHSHEDF----------HHGHSHAHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLY 102
            |.::|:|          ||.|.|.|.|||.|..  |.|.|||||||.|...||||.|.:.|:..:
  Fly    48 REANENFDPQKAPRAEHHHHHDHDHDHGHHHHG--HDHDHDHDHGHDHGHHHHGHDHDHDHDHGH 110

Human   103 HRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRS 167
            |. ||||..|:..          |.|||..|:|.:::|:|:|||||||.:|::||:: ||...:.
  Fly   111 HH-HGHDERHTKA----------KPDLDMSTIWLHSIGSTLLISAAPFVLLYIIPLD-NSEAMKP 163

Human   168 LLQILLSFASGGLLGDAFLHLIPHALEPHS--------------HHTLEQPGHGHSHSGQGPILS 218
            .|::||:||||||||||||||||||..|||              ||..|:..|||||.     :|
  Fly   164 RLKVLLAFASGGLLGDAFLHLIPHATHPHSHGEHGHDHGHDHHHHHDGEEHEHGHSHD-----MS 223

Human   219 VGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKET 283
            :|||||.||:|||.|||.||.:|||||   ||||       |||..:.:....:|:||::|:.
  Fly   224 IGLWVLGGIIAFLSVEKLVRILKGGHG---GHGH-------SHGAPKPKPVPAKKKSSDKEDS-- 276

Human   284 RGVQKRRGGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLG 348
                  ..|....|...::.:..|.|..| ::.:|||||||||.|||||||||||||:..|..:|
  Fly   277 ------GDGDKPAKPAKIKSKKPEAEPEG-EVEISGYLNLAADFAHNFTDGLAIGASYLAGNSIG 334

Human   349 ILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGG 413
            |:||:|:||||||||:||||||::||||:::||.|||:||:|||||||.|||..||..||
  Fly   335 IVTTITILLHEVPHEIGDFAILIKSGCSRRKAMLLQLVTALGALAGTALALLGAGGGDGS----- 394

Human   414 AGPGWVLPFTAGGFIYVATVSVLPELLREASPL-QSLLEVLGLLGGVIMMVLIAHLE 469
             .| ||||||||||||:||||||||||.|::.| |||.|:..||.||.:|::||..|
  Fly   395 -AP-WVLPFTAGGFIYIATVSVLPELLEESTKLKQSLKEIFALLTGVALMIVIAKFE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A7	NP_001070984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..121		34/82 (41%)
		Zip	132..446	CDD:308248	176/327 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..310		18/67 (27%)
Catsup	NP_524931.1	Zip	129..446	CDD:280666	186/348 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159608
Domainoid	1	1.000	337	1.000	Domainoid score	I1117
eggNOG	1	0.900	-	-		E1_COG0428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	412	1.000	Inparanoid score	I1863
Isobase	1	0.950	-	0	Normalized mean entropy	S1421
OMA	1	1.010	-	-		QHG57827
OrthoDB	1	1.010	-	-		D548499at33208
OrthoFinder	1	1.000	-	-		FOG0001345
OrthoInspector	1	1.000	-	-		oto91058
orthoMCL	1	0.900	-	-		OOG6_103840
Panther	1	1.100	-	-	LDO	PTHR16950
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1954
SonicParanoid	1	1.000	-	-		X2900
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750