DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galnt1 and Pgant9

DIOPT Version :9

Sequence 1:	NP_077349.1	Gene:	Galnt1 / 79214	RGDID:	620358	Length:	559	Species:	Rattus norvegicus
Sequence 2:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	263/533 - (49%)
Similarity:	342/533 - (64%)	Gaps:	25/533 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat    35 EEKKERGLPAGDVLELVQKP---HEGPGEMGKPVVIPKEDQEKMKEM----FKINQFNLMASEMI 92
            |:.|::  |..|..:::..|   .|.|||:||||.:|||..::||:.    :..|.||...|::|
  Fly   122 EQPKKK--PQEDSKKVIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLI 184

  Rat    93 AFNRSLPDVRLEGCKTKV-YPDSLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDD 156
            :.:|:|||.|...||.:. |..:||.|.|:|.||||||:.||||||||::|||.|:|.:|:||||
  Fly   185 SVHRTLPDPRDAWCKDEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDD 249

  Rat   157 ASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEP 221
            .|:...|||.||.|..... .|.:||.::|.||||||:.||..:|..|:|:||:|||||.|||||
  Fly   250 YSDMPHLKRQLEDYFAAYP-KVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEP 313

  Rat   222 LLARIKHDRRTVVCPIIDVISDDTFE--YMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTL 284
            ||.||..:..|||||:||||||:|.|  |.....:..|||:|.|.|.|:|||:||. :|......
  Fly   314 LLDRIARNSTTVVCPVIDVISDETLEYHYRDSGGVNVGGFDWNLQFSWHPVPERER-KRHNSTAE 377

  Rat   285 PVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKA 349
            ||.:||||||||||||::|..:||||:|.|||||||||:||:.|.||||||||.||||||:|||.
  Fly   378 PVYSPTMAGGLFSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKR 442

  Rat   350 TPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRVGLRHKLQCKPFSWY 414
            :||.:..|. .::.||:.|||||||||:..::| ...|..|.|:||:|.|..||:.|:||.|.||
  Fly   443 SPYKWRSGV-NVLKKNSVRLAEVWMDEYSQYYY-HRIGNDKGDWGDVSDRRKLRNDLKCKSFKWY 505

  Rat   415 LENIYPDSQIPRHYFSLGEIRNV--ETNQCLDNMARKENEK--VGIFNCHGMGGNQVFSYTANKE 475
            |:||||:..||....:.|||||:  ....|||..|.|:::|  ||.:.||..||||.:..:...|
  Fly   506 LDNIYPELFIPGDSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTYPCHRQGGNQYWMLSKAGE 570

  Rat   476 IRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDC 540
            ||.||.|||.:  ...||:..||..||||.|.|......|.|..|.:||  |..|......:.:|
  Fly   571 IRRDDSCLDYA--GKDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCL--AISESKDKLLMEEC 631

  Rat   541 TGSRS-QQWLLRN 552
            :.|.| |||.|.|
  Fly   632 SASLSRQQWTLEN 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galnt1	NP_077349.1	Catalytic subdomain A	115..225		65/109 (60%)
		pp-GalNAc-T	119..419	CDD:133004	172/301 (57%)
		Catalytic subdomain B	285..347		46/61 (75%)
		Ricin_B_lectin	432..548	CDD:395527	48/120 (40%)
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	158/274 (58%)
		pp-GalNAc-T	213..510	CDD:133004	172/300 (57%)
		Ricin_B_lectin	521..640	CDD:279046	48/122 (39%)
		RICIN	523..642	CDD:238092	50/122 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52215
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102903
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.730