Protein Alignment DDX39B and eIF4A

DIOPT Version :10

• Sequence 1: NP_004631.1
• Gene: DDX39B / 7919
• HGNCID: 13917
• Length: 428
• Species: Homo sapiens
• Sequence 2: NP_476595.1
• Gene: eIF4A / 33835
• FlyBaseID: FBgn0001942
• Length: 403
• Species: Drosophila melanogaster
• Alignment Length: 408
• Identity: 157/408 - (38%)
• Similarity: 236/408 - (57%)
• Gaps: 14/408 - (3%)

Human    15 DDEVETAAGGDGAEAPAKKDVKGSYVSI-HS--SGFRDFLLKPELLRAIVDCGFEHPSEVQHECI 76
            ||..|....|     ||..:.:|...|. |.  ..|.|..|:.||||.|...|||.||.:|...|
  Fly     2 DDRNEIPQDG-----PASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAI 61

Human    77 PQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMP 141
            ...:.|.||:.||:||.||||.|.:|.|||::....:...|::..|||||.||.:......:||
  Fly    62 IPCVRGRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYM- 125

Human   142 NVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLD 206
            .|......||.::::|..:|:..| |:|||||||:..:...|.|..::||.|:|||.|:||.: .
  Fly   126 KVHSHACIGGTNVREDARILESGC-HVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSR-G 188

Human   207 MRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLK- 270
            .:..:|::|:|.|.:.||::.|||:..::..|.|.||:||:.|.|..| :|||.|::|:||.:|
  Fly   189 FKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKE-ELTLEGIKQFYVNVKQ 252

Human   271 DNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKD 335
            :|.|...|.||.|.|...|.|||..:.::...|.|.:...||...|:|..|.|.:|....:||:.
  Fly   253 ENWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRS 317

Human   336 FQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKIL 400
            ...|:|:.|:|..||:|:::|::..|||:|.:.:.|:||:.|.||||.||:||.|::|: |.:||
  Fly   318 GSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDD-DRRIL 381

Human   401 NDVQDRFEVNISELPDEI 418
            .|::..:...|.|:|..|
  Fly   382 KDIEQFYHTTIEEMPANI 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX39B	NP_004631.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		4/15 (27%)
		DEADc_DDX39	44..251	CDD:350708	82/208 (39%)
		Q motif	45..73		13/27 (48%)
		DECD box	196..199		2/2 (100%)
		SF2_C_DEAD	262..391	CDD:350174	50/129 (39%)
eIF4A	NP_476595.1	DEAD-like_helicase_N	6..403	CDD:475120	155/404 (38%)