DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DDX39B and Hel25E

DIOPT Version :9

Sequence 1:	NP_004631.1	Gene:	DDX39B / 7919	HGNCID:	13917	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_723089.1	Gene:	Hel25E / 33781	FlyBaseID:	FBgn0014189	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	360/426 - (84%)
Similarity:	390/426 - (91%)	Gaps:	5/426 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAENDVDNELLDYEDDEVETAAGGDGAEAPAKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGF 65
            ||:||   :||||||:|.......:..||| ||||||:|||||||||||||||||:|||||||||
  Fly     1 MADND---DLLDYEDEEQTETTAVENQEAP-KKDVKGTYVSIHSSGFRDFLLKPEILRAIVDCGF 61

Human    66 EHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQV-SVLVMCHTRELAFQI 129
            ||||||||||||||:||||:||||||||||||||||||||||||..... .||||||||||||||
  Fly    62 EHPSEVQHECIPQAVLGMDILCQAKSGMGKTAVFVLATLQQLEPSDNNTCHVLVMCHTRELAFQI 126

Human   130 SKEYERFSKYMPNVKVAVFFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFI 194
            ||||||||||||.|||||||||::|:||||.||...||||||||||||||.|||.||||.:|||:
  Fly   127 SKEYERFSKYMPTVKVAVFFGGMAIQKDEETLKSGTPHIVVGTPGRILALIRNKKLNLKLLKHFV 191

Human   195 LDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTL 259
            ||||||||||||||||||||||.|||.||||||||||||:|||||:||||||||::||||.||||
  Fly   192 LDECDKMLEQLDMRRDVQEIFRSTPHGKQVMMFSATLSKDIRPVCKKFMQDPMEVYVDDEAKLTL 256

Human   260 HGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQE 324
            |||||:||.||:||||:|||:||||||||||||||||||||:||:|||.|||||||.|||||.||
  Fly   257 HGLQQHYVNLKENEKNKKLFELLDVLEFNQVVIFVKSVQRCVALSQLLTEQNFPAIGIHRGMTQE 321

Human   325 ERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAIT 389
            |||:|||||||||:||||||||||||||||||||.||||||||||||||||||||||||||||||
  Fly   322 ERLNRYQQFKDFQKRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAIT 386

Human   390 FVSDENDAKILNDVQDRFEVNISELPDEIDISSYIE 425
            ||||||||||||:|||||:|||||||:|||:|:|||
  Fly   387 FVSDENDAKILNEVQDRFDVNISELPEEIDLSTYIE 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDX39B	NP_004631.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		13/29 (45%)
		DEADc_DDX39	44..251	CDD:350708	179/207 (86%)
		Q motif	45..73		26/27 (96%)
		DECD box	196..199		2/2 (100%)
		SF2_C_DEAD	262..391	CDD:350174	115/128 (90%)
Hel25E	NP_723089.1	DEADc_DDX39	40..248	CDD:350708	179/207 (86%)
Hel25E	NP_723089.1	SF2_C_DEAD	259..388	CDD:350174	115/128 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1638
eggNOG	1	0.900	-	-		E2759_KOG0329
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48376
Inparanoid	1	1.050	722	1.000	Inparanoid score	I631
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54017
OrthoDB	1	1.010	-	-		D274153at33208
OrthoFinder	1	1.000	-	-		FOG0001601
OrthoInspector	1	1.000	-	-		otm41210
orthoMCL	1	0.900	-	-		OOG6_101150
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1410
SonicParanoid	1	1.000	-	-		X1003
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870