Protein Alignment TMEM43 and Tmem43

DIOPT Version :10

• Sequence 1: NP_001394203.1
• Gene: TMEM43 / 79188
• HGNCID: 28472
• Length: 401
• Species: Homo sapiens
• Sequence 2: NP_648162.2
• Gene: Tmem43 / 38881
• FlyBaseID: FBgn0035825
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 382
• Identity: 127/382 - (33%)
• Similarity: 195/382 - (51%)
• Gaps: 55/382 - (14%)

Human    29 LSETSGG----MFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPEN----E 85
            ||||...    ...|::.|:.....::.|||||:....:|.|..:.:.   |:.....|.    |
  Fly     4 LSETLRSHWPIALFGVILFVAGGTELYWNEGRAVHNMMALDEAHADIY---SVRFTEEEQEVGLE 65

Human    86 GRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTED-GQVKKETRYSYTD 149
            ||:||:.|.:...:.|::|:|.:.|.||||||.|:||||||......|.:. |....::|..|..
  Fly    66 GRIVHLSGPILVGEPLTEPDYNIQLLAVKLRRRVQMYQWVEEAVEHNYGDSVGTTHSDSRTYYYT 130

Human   150 TEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLS-KLE 213
            .|||.:|::|:||....||.|||...:||.:..|..|.|||:.|.:.:.:|.:|::.|:.. :.|
  Fly   131 REWRDKIVDSRNFYNRHGHTNPSHFPIESHVQVADAVFIGRYELGAEVKEKFNNYQELTSDIRPE 195

Human   214 DP----HVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLV 274
            |.    |:.|      :||:.:...|||||||:.||:||:.|:        |.:|:.:..|::||
  Fly   196 DSGVKLHLGI------YYHTNDVFNPEVGDLRLLFSFAGMEGE--------VFSVVGKLSGNKLV 246

Human   275 PFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLV---- 335
            |:.|..|..:||::.|..|.:|||..|.|:..:.||..|..||:.:|.|:...|:||..|.
  Fly   247 PYITSRGVPVLLVYPGGLSVQEVFRLEARAQVLHTWWWRFVGWLLIFFGVTCNTKILRLLFVRVP 311

Human   336 --------DWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPL--WALLIAG 382
                    ..|||..:|:          :|.||.|...|..|:.:||:  ..||:||
  Fly   312 LLVALAPDPQFPVTGNLL----------IAFSLALTIAAVAWILHRPVIGACLLLAG 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMEM43	NP_001394203.1	TMEM43	121..374	CDD:462267	89/270 (33%)
Tmem43	NP_648162.2	TMEM43	101..348	CDD:462267	89/270 (33%)