DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FBXL15 and CG5003

DIOPT Version :9

Sequence 1:	XP_005270206.1	Gene:	FBXL15 / 79176	HGNCID:	28155	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_651593.1	Gene:	CG5003 / 43344	FlyBaseID:	FBgn0039554	Length:	713	Species:	Drosophila melanogaster

Alignment Length:	272	Identity:	62/272 - (22%)
Similarity:	100/272 - (36%)	Gaps:	68/272 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   116 LPHVLNRVPLRQLLRLQRVSRAFRSLVQLHL----AGLRRFD----AAQVGPQIPRAALARLLRD 172
            |..|..||...::|.|:.||..|.   .:|:    |.|||..    :.:|| ..|::....:...
  Fly   160 LSSVFPRVVQLKVLELEGVSLDFE---YIHITEFPATLRRLKLKDCSVRVG-DTPKSIFYSIELH 220

Human   173 AEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRA-LGALAE--GCPRLQRLSL 234
            ...|::|::.. :.|. :...:..|::.|.||.::|.||..|.:.. .|::|.  |..:|:.|.|
  Fly   221 LLDLEDLSIED-NSWF-EPYYIMGLSKLPSLRRLSLKGCQALCKFVPYGSMAARFGFQKLESLDL 283

Human   235 AHCDWVDGLALRGLADRCPALEELDL---TACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDA 296
                            |...:...||   :|...||:     |.......|.|.......|....
  Fly   284 ----------------RQTPINNSDLQCFSAIENLKE-----LLLESPQILHSKQAVAKKNTNGN 327

Human   297 AVQELARNCPELHHLDLTGCLRVGSDG----VRTLAEYCPVLRSLRVR----HCHHVAESSLSRL 353
            |..|.|...|:        .|:|.||.    .|...|:   ||:.:|.    :|        |..
  Fly   328 ATDEAASPQPD--------SLKVLSDDEPSTSRAAMEH---LRACKVAFNLDNC--------SDR 373

Human   354 RKRGVDIDVEPP 365
            ::....:..|||
  Fly   374 KEEKSPVPTEPP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXL15	XP_005270206.1	F-box	105..>142	CDD:279040	9/25 (36%)
		leucine-rich repeat	149..175	CDD:275381	6/29 (21%)
		leucine-rich repeat	176..202	CDD:275381	4/25 (16%)
		leucine-rich repeat	203..228	CDD:275381	9/27 (33%)
		AMN1	<226..>353	CDD:187754	28/137 (20%)
		leucine-rich repeat	229..254	CDD:275381	4/24 (17%)
		leucine-rich repeat	255..281	CDD:275381	6/28 (21%)
		leucine-rich repeat	282..307	CDD:275381	6/24 (25%)
		leucine-rich repeat	308..332	CDD:275381	6/27 (22%)
CG5003	NP_651593.1	F-box	68..114	CDD:279040
CG5003	NP_651593.1	leucine-rich repeat	610..635	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930