DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FBXL15 and CG14891

DIOPT Version :9

Sequence 1:	XP_005270206.1	Gene:	FBXL15 / 79176	HGNCID:	28155	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_650560.1	Gene:	CG14891 / 42013	FlyBaseID:	FBgn0038445	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	73/320 - (22%)
Similarity:	112/320 - (35%)	Gaps:	81/320 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    99 QEPGAVRFLDLPWEDVLLPHVLNRVPLRQLLRLQRVSRAFRSLVQL------HLAGLRRFDAAQV 157
            :|.|.:...|||..|.:...||:.:.|.:.|........|:::.:|      |:..::     .|
  Fly   104 EESGTLSAYDLPITDDIWWKVLDYLSLNERLNFAASCERFQAIYELDSHRINHVLNMK-----DV 163

Human   158 GPQIPRAALARLLRDAEGLQELALAPCH-EWLSDEDLVPVLARNPQLRSVALGGCGQLSRRALGA 221
            .....|.....:|...:.:..:...|.| .|       |.|....||..|:
  Fly   164 CTLTHRVIKRLMLLSGKHIHCVTGGPLHPNW-------PYLTEFVQLLGVS-------------- 207

Human   222 LAEGCPRLQRL-------SLAHCDWV-DGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQR- 277
                ||.|..|       ||||...: ||  ..||.:    :..:.|..| .||| |.:|..|.
  Fly   208 ----CPNLTELSFFKISVSLAHMTHLFDG--ANGLIN----ITNISLRRC-NLKD-AHIYCLQML 260

Human   278 --------------RGAGLRSLSLAVN-ANVGDAAVQELARNC-------PELHHLDLTGCLRVG 320
                          :|..|:||.:::. .||....  :|:..|       ..|..|...|.::..
  Fly   261 SKLKSLDIRENFSIKGDSLKSLPISLEILNVSGCV--DLSPKCLIQLAALSHLRELRCPGIVKFA 323

Human   321 SDG--VRTLAEYCPVLRSLRVRHCHHVAE-SSLSRLRKRGVDIDVEPPLHQALVLLQDMA 377
            .|.  ...||.|||:|..|.:....:|.: ..||||....:....:...|...|||..:|
  Fly   324 KDNELYGRLAHYCPMLEVLELTDFMNVIQLGGLSRLHTLVIHSSAQLDYHVNNVLLTSIA 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXL15	XP_005270206.1	F-box	105..>142	CDD:279040	9/36 (25%)
		leucine-rich repeat	149..175	CDD:275381	3/25 (12%)
		leucine-rich repeat	176..202	CDD:275381	5/26 (19%)
		leucine-rich repeat	203..228	CDD:275381	3/24 (13%)
		AMN1	<226..>353	CDD:187754	42/160 (26%)
		leucine-rich repeat	229..254	CDD:275381	10/32 (31%)
		leucine-rich repeat	255..281	CDD:275381	9/40 (23%)
		leucine-rich repeat	282..307	CDD:275381	7/32 (22%)
		leucine-rich repeat	308..332	CDD:275381	7/25 (28%)
CG14891	NP_650560.1	RRM_6	25..91	CDD:290958
		AMN1	<199..352	CDD:187754	43/180 (24%)
		leucine-rich repeat	211..237	CDD:275381	9/27 (33%)
		leucine-rich repeat	239..262	CDD:275381	8/24 (33%)
		leucine-rich repeat	263..285	CDD:275381	4/21 (19%)
		leucine-rich repeat	286..338	CDD:275381	12/53 (23%)
		leucine-rich repeat	339..387	CDD:275381	12/45 (27%)
		leucine-rich repeat	388..415	CDD:275381
		leucine-rich repeat	416..439	CDD:275381
		leucine-rich repeat	440..465	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930