DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FBXL15 and CG12402

DIOPT Version :9

Sequence 1:	XP_005270206.1	Gene:	FBXL15 / 79176	HGNCID:	28155	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster

Alignment Length:	287	Identity:	72/287 - (25%)
Similarity:	115/287 - (40%)	Gaps:	64/287 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   114 VLLPHVLNRV----PLRQLLRLQRVSRAFRSLVQLHLAG-----LRRFD---AAQVGPQIPRAAL 166
            |||..||..|    |:|||.....:|.....|  |::||     |:..|   ..|:     .|..
  Fly   316 VLLEAVLRAVPESAPIRQLDLTGMLSLTNELL--LYVAGKWQSTLKVLDLMFCVQL-----NANC 373

Human   167 ARLLRDAEG-LQELALAPCHE---------------------------WLSDEDLVPVLARNPQL 203
            ...||...| |:.|.:|.|.|                           :|.:..:..:|.|.|.|
  Fly   374 IDALRQLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNL 438

Human   204 RSVALGGCGQ-LSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLAD------RCPALEELDLT 261
            |.::|..|.| ::.|.:..:.:...||:.|::.:|..:....|.|..|      |...|:||:|.
  Fly   439 RRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLR 503

Human   262 ACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRT 326
            .||.:.|.::  :...:...||:|||.....:.....:.|.:|||.|..|.::.|:.|..:.|..
  Fly   504 GCRNVTDSSL--MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLN 566

Human   327 LAEYCPVLRSLRVRHC--------HHV 345
            :......||.|.:.:|        ||:
  Fly   567 IVSNLKRLRVLNLSNCTKLTLQSIHHI 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXL15	XP_005270206.1	F-box	105..>142	CDD:279040	11/31 (35%)
		leucine-rich repeat	149..175	CDD:275381	6/28 (21%)
		leucine-rich repeat	176..202	CDD:275381	8/52 (15%)
		leucine-rich repeat	203..228	CDD:275381	6/25 (24%)
		AMN1	<226..>353	CDD:187754	35/134 (26%)
		leucine-rich repeat	229..254	CDD:275381	7/30 (23%)
		leucine-rich repeat	255..281	CDD:275381	7/25 (28%)
		leucine-rich repeat	282..307	CDD:275381	8/24 (33%)
		leucine-rich repeat	308..332	CDD:275381	5/23 (22%)
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	41/172 (24%)
		leucine-rich repeat	304..330	CDD:275381	6/13 (46%)
		leucine-rich repeat	331..357	CDD:275381	8/27 (30%)
		leucine-rich repeat	358..379	CDD:275381	5/25 (20%)
		leucine-rich repeat	384..409	CDD:275381	5/24 (21%)
		leucine-rich repeat	412..437	CDD:275381	3/24 (13%)
		AMN1	430..595	CDD:187754	44/166 (27%)
		leucine-rich repeat	438..464	CDD:275381	6/25 (24%)
		leucine-rich repeat	465..496	CDD:275381	7/30 (23%)
		leucine-rich repeat	497..521	CDD:275381	7/25 (28%)
		leucine-rich repeat	522..547	CDD:275381	8/24 (33%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010