Protein Alignment ALDH5A1 and Ssadh

DIOPT Version :10

• Sequence 1: NP_733936.1
• Gene: ALDH5A1 / 7915
• HGNCID: 408
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_651408.1
• Gene: Ssadh / 43092
• FlyBaseID: FBgn0039349
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 267/553 - (48%)
• Similarity: 364/553 - (65%)
• Gaps: 56/553 - (10%)

Human     5 IWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRW 69
            :|.:..|..|.||:...||:|                           |.| ||::..:.|.|.|
  Fly     1 MWRQLSGVARTGSSLSLCRMR---------------------------GFS-ALVQDKALVDGAW 37

Human    70 LP---AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKERSSLLRKWYN 129
            :.   |.|||.|::||:||.:|.|.:..|.:|:.|:.||.:|:  ..||.::||:||:||:||:.
  Fly    38 VDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRSNLLKKWHK 102

Human   130 LMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194
            |:.|:..::|.|:|||||||:.|:.||:.|...|:|||:|||||:||:|:.:.:.:|..:|:|||
  Fly   103 LIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWFAEEARRIYGEIVPSASPNREIIVMKQP 167

Human   195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQ 259
            |||||:|||||||.||||||.||||||||||||||:||||.:|||:|:             ||..
  Fly   168 IGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAK-------------LAVD 219

Human   260 AGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLA 324
            ||||.||.||:..::  |..:|:..|..|.|..|||||||..||:|..::|:.:||:.:||||.|
  Fly   220 AGIPKGVINVVTTNK--AAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGNA 282

Human   325 PFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV---KAFAEAMKKNLRVGNG 386
            ||||||||::::||.|||||||||.|||||.:|:|.||..::|.||   |...||:|    :|:|
  Fly   283 PFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALK----IGDG 343

Human   387 FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK-RHQLGKNFFEPTLLCNVTQDMLCTHE 450
            .......||||||....||...|.||.||.|.::.||: ....|..|:.||::.:|........|
  Fly   344 QGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSE 408

Human   451 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVEC 515
            |.|||:..:|:|..||||:..||....||||||||::..|::|||::|||||||||||:||:.|.
  Fly   409 EVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEA 473

Human   516 PFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL 548
            ||||||:||:||||||:|||:|:::||:|.|.|
  Fly   474 PFGGVKESGVGREGSKHGIDDYVDIKYICMGNL 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	243/468 (52%)
Ssadh	NP_651408.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	245/472 (52%)