Protein Alignment ALDH5A1 and CG8665

DIOPT Version :10

• Sequence 1: NP_733936.1
• Gene: ALDH5A1 / 7915
• HGNCID: 408
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 498
• Identity: 168/498 - (33%)
• Similarity: 267/498 - (53%)
• Gaps: 36/498 - (7%)

Human    61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC-RWREVSAKERSS 122
            |..|:.|.::.|.|  |..:.:|.:...|..||.....:...|||||:.||. .||:::.::|..
  Fly   433 TQLFINGEFVDAEAQRTLEIVNPTNEEVLCKVACASATDVDKAVRAAHSAFYGSWRQITPRQRGQ 497

Human   123 LLRKWYNLMIQNKDDLARIITAESGK----PLKEAHGEILYS-AFFLEWFSEEARRVYGDIIH-T 181
            |:....:||.:||::||.|.:.:||.    .||...|..:.: .:|..|    ..::.|:.|. .
  Fly   498 LMLNLADLMERNKEELATIESVDSGAVYTLALKTHVGMSIEAWRYFAGW----CDKIQGNTIPVN 558

Human   182 PAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVN 244
            ||:....|..  |:||||..:|||||:|..|::.|:.|.:|||.|.::|||:..|.:||..||
  Fly   559 PARPNNVLTFTRKEPIGVCGLITPWNYPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAE-- 621

Human   245 QGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 309
                       |..:||.|.||.||:|   ....:.|:|:....||.|:.|||||..||.::...
  Fly   622 -----------LTVRAGFPPGVINVLP---GKGSDAGQAVADHELVRKLGFTGSTPIGKHIMKSC 672

Human   310 ANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF 373
            |:| :|:.|:||||.:|.|:|...::|:||...|:|.|.|.|:.|:.:.:..|:..|||.|::..
  Fly   673 ADSNLKKCSLELGGKSPLIIFADCDMDKAVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRV 737

Human   374 AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR-HQLGKNFFEPTL 437
            .:.: :.:.:|:..:..|..||..::...:|:.:.....|.:||.:|.||.| ..|...||.||:
  Fly   738 LKDL-RTMTIGDPLDRSTAHGPQNHKAHFDKLLEFCRRGVDEGAKLVYGGCRVPNLKGYFFTPTV 801

Human   438 LCNVTQDMLCTHEETFGPLAPVIKFDTE--EEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 500
            ..|||.||....||:|||:..:.||:..  :..:..||..:.|||...:::|..:....|:::|.
  Fly   802 FTNVTDDMFIAQEESFGPIMIISKFNGSDIDSLMQRANRTEYGLASGVFTKDIGKALNFADRIEA 866

Human   501 GMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 543
            |.|.||....:.|..||||.||||.|::..:..::|||:.|.|
  Fly   867 GTVFVNVYNKTDVAAPFGGFKQSGYGKDLGQEALNEYLKTKCV 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	160/475 (34%)
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	336..394	CDD:425746
		ALDH_F1L_FTFDH	428..913	CDD:143458	168/498 (34%)