Protein Alignment ALDH5A1 and P5CDh2

DIOPT Version :10

• Sequence 1: NP_733936.1
• Gene: ALDH5A1 / 7915
• HGNCID: 408
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_788705.1
• Gene: P5CDh2 / 32625
• FlyBaseID: FBgn0053092
• Length: 614
• Species: Drosophila melanogaster
• Alignment Length: 478
• Identity: 110/478 - (23%)
• Similarity: 190/478 - (39%)
• Gaps: 108/478 - (22%)

Human   101 AVRAAYEAFCRWREVSAK------ERSSLL---RKWYNLMIQNKDDLARIITAE---SGKPLKEA 153
            |:..:.||..:|.:|...      ||:::|   |..||           ||.|.   .||.|::|
  Fly   123 AIDKSVEAQVKWDKVRLSDRIDIWERAAMLIAGRYRYN-----------IIAATMLGQGKTLRQA 176

Human   154 HGEILYSAFFLE----WFSEEARRVYGDIIHTPAKD-----RRALVLKQPIGVAAVITPWNFPSA 209
            ..::.....|:.    :..|.|.       :.|.:|     |.::.|:...|..|.|:|:||..
  Fly   177 EMDVAELVDFMRINPVFLRELAN-------YEPIRDIQNNCRNSMRLRGLSGFVAAISPFNFTG- 233

Human   210 MITRKVGAALA-----AGCTVVVKPAEDT------PFSALALAEVNQGFLLDLDPLLLASQAGIP 263
                 :.|.||     .|.:|:.||::..      .|.||                   .:||:|
  Fly   234 -----IAANLAYTPALMGNSVIWKPSDSAILSNYFVFKAL-------------------REAGVP 274

Human   264 SGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVK------RVSMELGG 322
            .||.|.:|........|   :...|.::.|:|||::|..|:|....|.::.      |:..|.||
  Fly   275 DGVVNFVPAEETTFASV---VTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVGEGGG 336

Human   323 LAPFIVFDSANVDQAVAGAMASKFRNTGQTC-VCSNQF----LVQRGIHDAFVKAFAE-AMKKNL 381
            .....|..||..:.|||..:.:.|...||.| .||..:    |.|..|.:..::..|. .::::.
  Fly   337 KNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSMLYVPESLWQNHIREPLLEITASLVVRQDA 401

Human   382 RVGNGFEEGTTQGPLINEKAVEKVE---KQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQ 443
            ...:.|     ...:||.:|.:::.   :.::.  |....::.||...:....:.:||::.....
  Fly   402 TYCDSF-----CSAVINRRAYDRIYMWLRYIDQ--SPSCQILVGGSCDKRRGYYVDPTVVLVKDL 459

Human   444 DMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV--GLAGYFYSQDPAQIWRV--AEQLEVGMVG 504
            |.:...||...|:..|..:...:....:...|.:  ||.|..::||...|...  |.::.||.:.
  Fly   460 DNIICREELLAPILGVYVYPDHKLKETMEKVAQINHGLTGSVFAQDQNFIEEAYDAFRVNVGNLN 524

Human   505 VNE---GLISSVECPFGGVKQSG 524
            ||:   ||:...: |||....:|
  Fly   525 VNDKSTGLMVGQQ-PFGAGHMTG 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	110/478 (23%)
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:448367	110/478 (23%)