DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fgr and Src42A

DIOPT Version :9

Sequence 1:	NP_077059.2	Gene:	Fgr / 79113	RGDID:	621319	Length:	517	Species:	Rattus norvegicus
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	235/416 - (56%)
Similarity:	294/416 - (70%)	Gaps:	22/416 - (5%)

- Green bases have known domain annotations that are detailed below.

  Rat   104 EARSLSSGRTGYVPSNYVAPVDSIQAEEWYFGKISRKDAERQLLSDGNPQGAFLIRESETTKGAY 168
            ::|.||....|          :.:..:.|||.||.|.:||::||...|..||||||:||:....|
  Fly  1192 KSRRLSEFTRG----------EFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDY 1246

  Rat   169 SLSIRDWDQNRGDHIKHYKIRKLDMGGYYITTRAQFESVQDLVRHYMEVNDGLCYLLTAPCM-VM 232
            |||:||     ||.:|||:||:||.||::|..|..|.::|:||.||.:.:||||..|..||: :.
  Fly  1247 SLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIE 1306

  Rat   233 KPQTLGLA---KDAWEIDRNSIALDRRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEE 294
            ||.|.||:   :|.|||||.|:...|:||:|.|||||.|.||.:|.||:||||.|||.||.||.|
  Fly  1307 KPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAE 1371

  Rat   295 AQIMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCYGSLLDFLK--DRKGHNLMLPNLVDMAAQVAE 356
            |||||.|||.||:|||||.: ||||||:||.|.:||||::|:  ..||.:|.:..|:|||||:|.
  Fly  1372 AQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAA 1436

  Rat   357 GMAYMERMNYIHRDLRAANILVGEHLICKIADFGLARLIVDDEYNPQQGTKFPIKWTAPEAALFG 421
            ||||:|..|||||||.|.|:|||:..|.|||||||||||.:|||..:.|.:|||||||||||.:.
  Fly  1437 GMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYS 1501

  Rat   422 RFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLD 486
            :|::||||||||||||||:|.||:|||||.|.|||.||||||.||.||.|...|||:|.:.|..|
  Fly  1502 KFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKD 1566

  Rat   487 PEERPTFEYLQSFLEDYFTSTEPQYQ 512
            |..|||||.||..|||::||.:..|:
  Fly  1567 PMRRPTFETLQWKLEDFYTSDQSDYK 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fgr	NP_077059.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..46
		SH3	68..125	CDD:418401	4/20 (20%)
		SH2_Src_Fgr	128..228	CDD:198230	49/99 (49%)
		PKc_like	255..502	CDD:419665	163/249 (65%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	49/95 (52%)
		PTKc_Frk_like	1319..1587	CDD:270653	173/267 (65%)
		Pkinase_Tyr	1328..1580	CDD:285015	162/251 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8819
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930