DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASTKD3 and CG31643

DIOPT Version :9

Sequence 1:	NP_076996.2	Gene:	FASTKD3 / 79072	HGNCID:	28758	Length:	662	Species:	Homo sapiens
Sequence 2:	NP_001285652.1	Gene:	CG31643 / 318867	FlyBaseID:	FBgn0051643	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	691	Identity:	143/691 - (20%)
Similarity:	238/691 - (34%)	Gaps:	224/691 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    73 LHPLGGPVFSQVSDCDRLEQNVKNEESQMFYRRLSNLTSSEEVLSFISTMETLPDTMAAGALQRI 137
            :|.|..||:||                          |.::.:...:..:......|.:..|:.|
  Fly   279 IHMLNIPVWSQ--------------------------THTQLIREVMLVLRPCIHQMESADLKSI 317

Human   138 C-------------EVEKKDGDQGLPKEILENSIFQALCF-----------QFE-----KEPSQL 173
            |             |..||..::.|.:|...:::|.|:.|           ||:     :|..|.
  Fly   318 CRTFLHHQEPAALIEPLKKALEKLLQEEGTADALFCAVPFATPLQRDQYLHQFKELLYSEEAWQQ 382

Human   174 SNTS--LVTALQALILLHVD----------------PQSSLLLNLVAECQ------NRLRKGG-- 212
            .|.|  |.:.|:||.:..::                |:..|.|..:..||      |.|  ||
  Fly   383 PNASGHLFSVLRALKVSDIEFCNTYWSGVVKELESCPEKHLHLRFLRHCQRYMNFNNNL--GGTY 445

Human   213 ------MEVRNLCI-------------------------------------------------LG 222
                  .::..:|:                                                 ||
  Fly   446 RHLELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAWKKFPNFLLSKMLAMAPQLG 510

Human   223 ESLITLHSSGC-VTLELIINQ----LQGEKLETFTPEDIVALYRILQACTEKVDEHQTFLNK--I 280
            .....|.|.|. :..||...|    |.|.:|.|        :..||..|.|:   |.....|  :
  Fly   511 IQDCFLLSRGMQIASELRFRQHLPALAGMQLST--------MDSILIGCAER---HLRDAEKDPL 564

Human   281 NNFSLS-IVSNLSPKLISQMLTALVVLDQSQAFPLIIKLGKYVVRHVPHFTNEELRRVLEAFIYF 344
            |...|| ||..||.:   :.|...||.:|:        |.:|...|    .|:...||:....|.
  Fly   565 NASELSMIVRTLSHR---KKLKNTVVYNQA--------LAQYKNLH----CNDLNSRVVRDMAYN 614

Human   345 GHHDTFFTKALEHRVAAVCLTLDPEVVCRVMEYCSRELILSKPILNAVAETFVCQTEKFSPRQIS 409
            .:...||.               ||::..:..|.|.                  |.:..|...:.
  Fly   615 FNASNFFV---------------PELLESMFAYISE------------------QHDHVSGDTVE 646

Human   410 ALMEPFGKLNYLPPNASALFRKLENVLFTHFNYFPPKSLLKLLHSCSLNECHPVNFLAKIFKPLF 474
            .::.....|.|:|.:..||....| ||...|:.....|:::...:....:..|...:.::|...|
  Fly   647 KVLTCSYNLGYMPASVEALNHASE-VLLRDFDQMSGLSVVQACLALCFYKSIPEQLINQVFCVKF 710

Human   475 LQRLQGKESHLDT-LSRAQLTQLFLASVLE-----CPFYKGPKL-LPKYQVKSFLTPCCSLETPV 532
            :||:   |..:.. .|:|...:..|..|::     |..:  |:. :|.:| ::::....|.::.:
  Fly   711 IQRI---EDEIQVCYSKATYPERVLNLVMQLNRTVCLDF--PEANVPWFQ-QNYIEAQISKKSLI 769

Human   533 DSQLYRYVKIGLTNLLGARLYFAPKVLTPYCYTIDVEIKLDEEGFVLPSTANE----DIHKRIAL 593
            .|:....||..|..||....:|.....|||.|.||..|..|.:...:|:...|    |...::|:
  Fly   770 PSESTTEVKQLLHQLLQNDKHFRCNHTTPYGYQIDFVIHFDRDKNPIPAPPVEATMLDRITKVAI 834

Human   594 CIDGPKRFCSNS-KHLLGKEAIKQRHLQLLGYQVVQIPYHE 633
            .:.....||.|. ..|.|.|::|.|||:::||:|:||..|:
  Fly   835 LLLKLDSFCENDLTALRGPESLKMRHLEMMGYKVMQINEHD 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASTKD3	NP_076996.2	FAST_1	409..477	CDD:284217	13/67 (19%)
		FAST_2	493..579	CDD:285557	22/91 (24%)
		RAP	593..650	CDD:214932	16/42 (38%)
CG31643	NP_001285652.1	FAST_1	647..713	CDD:284217	13/66 (20%)
		FAST_2	736..816	CDD:285557	20/82 (24%)
		RAP	834..894	CDD:214932	16/42 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7659
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040