Protein Alignment REEP5 and ReepA

DIOPT Version :10

• Sequence 1: NP_005660.4
• Gene: REEP5 / 7905
• HGNCID: 30077
• Length: 189
• Species: Homo sapiens
• Sequence 2: NP_001188988.1
• Gene: ReepA / 37643
• FlyBaseID: FBgn0261564
• Length: 716
• Species: Drosophila melanogaster
• Alignment Length: 174
• Identity: 48/174 - (27%)
• Similarity: 85/174 - (48%)
• Gaps: 24/174 - (13%)

Human    35 SFIALGVIGLVALYLVFGYGAS--------LLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWV 91
            ||....:..|:.::|.....|.        |.|..:   ||||.|.||:.:.:.::..:|:.||:
  Fly   129 SFNTACICSLIVIFLAPRTCAQSLLFPAFRLFCGTL---YPAYASYKAVRTKDVKEYVKWMMYWI 190

Human    92 VYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMDSVV 156
            |:..|:..|.|:|||:||.||||.:|...:.|.::|: :.|:..||::.:.|...:||.::|..|
  Fly   191 VFAFFTCIETFTDIFISWLPFYYEVKVALVFWLLSPA-TKGSSTLYRKFVHPMLTRHEQEIDEYV 254

Human   157 KDLKDK------------AKETADAITKEAKKATVNLLGEEKKS 188
            ...|::            .....:.:.:.|.|...||:...|:|
  Fly   255 NQAKERGYSAVLQLGSKGVNYATNVLMQTAIKGGGNLVQTIKRS 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
REEP5	NP_005660.4	TB2_DP1_HVA22	67..144	CDD:460820	28/76 (37%)
		Required for dimerization and maintaining endoplasmic reticulum morphology. /evidence=ECO:0000269|PubMed:32075961	114..185		17/82 (21%)
ReepA	NP_001188988.1	TB2_DP1_HVA22	166..242	CDD:460820	28/76 (37%)