DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPATA5L1 and Spata5l1

DIOPT Version :9

Sequence 1:	NP_076968.2	Gene:	SPATA5L1 / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens
Sequence 2:	NP_001028428.2	Gene:	Spata5l1 / 214616	MGIID:	3036261	Length:	747	Species:	Mus musculus

Alignment Length:	753	Identity:	602/753 - (79%)
Similarity:	660/753 - (87%)	Gaps:	10/753 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAPDSDPFPEGPLLKLLPLDARDRGTQRCRLGPAALHALGARLGSAVKISLPDGGSCLCTAWPRR 65
            |||||.|||:|.||||||:|.|||.||||||||||..:|||||||.::||||.||.|||||||||
Mouse     1 MAPDSGPFPDGQLLKLLPVDPRDRDTQRCRLGPAAFRSLGARLGSPLRISLPAGGCCLCTAWPRR 65

Human    66 DGADGFVQLDPLCASPGAAVGASRSRRSLSLNRLLLVPCPPLRRVAVWPVLRERAGAPGARNTAA 130
            |..||||||||.||||||.|...|    :.::.|..||||||||:.||||||.:||||   ::||
Mouse    66 DRVDGFVQLDPQCASPGARVATGR----IGMDCLQPVPCPPLRRLEVWPVLRPQAGAP---SSAA 123

Human   131 VLEAAQELLRNRPISLGHVVVAPPGAPGLVAALHIVGGTPSPDPAGLVTPRTRVSLGGEPPSEAQ 195
            |||...|||||||:|.||||..|||.||.|||||::||||.|:|.|.|||.||::|..:||.:.:
Mouse   124 VLEVVHELLRNRPVSRGHVVTTPPGVPGPVAALHVMGGTPDPEPGGWVTPHTRITLSDKPPPQVE 188

Human   196 PQPEVPLGGLSEAADSLRELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGA 260
            |..||.||||||.|||||||||||||||.||.||||||||||||||||||||||||||||||.||
Mouse   189 PPGEVTLGGLSETADSLRELLRLPLRYPLALAALGLAVPRGVLLAGPPGVGKTQLVRAVARETGA 253

Human   261 ELLAVSAPALQGSRPGETEENVRRVFQRARELASRGPSLLFLDEMDALCPQRGS--RAPESRVVA 323
            ||||||||||||||||||||||||:||||:||||||||||||||:|||||:||.  |||||||||
Mouse   254 ELLAVSAPALQGSRPGETEENVRRIFQRAQELASRGPSLLFLDEVDALCPRRGGPHRAPESRVVA 318

Human   324 QVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPIS 388
            ||||||||...|||.||||||||||.|||||||||||||||||||||||||:.||||||||||||
Mouse   319 QVLTLLDGIHRDREFVVVGATNRPDELDPALRRPGRFDREVVIGTPTLKQREAILQVITSKMPIS 383

Human   389 SHVDLGLLAEMTVGYVGADLTALCREAAMHALLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVI 453
            ||:||||||||||||||||||||||||||.|||.:|||||:|.|:|.|||||||.||||||||..
Mouse   384 SHIDLGLLAEMTVGYVGADLTALCREAAMCALLKNEKNQDSPKIEETDFLEAFKKIQPSSFRSST 448

Human   454 GLMDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRAL 518
            ||||||||.||:|||||||||||||.:|||||||.||.|||||||||:|||||||||||||||||
Mouse   449 GLMDIKPVGWEQIGGLEDVKLKLKQCVEWPLKFPQEFARMGLTQPKGLLLYGPPGCAKTTLVRAL 513

Human   519 ATSCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQ 583
            ||.||||||||.||||||||||||||||||:||||||:|||::|||||||:||:||...:|||.:
Mouse   514 ATGCHCSFVSVCGADLFSPFVGDSEKVLSQVFRQARANTPALVFLDEIDSVLGSRSVGTSGCDAR 578

Human   584 ERVLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKII 648
            |||||||||||||||::|:||||||:||||.||:.:|||||:.|||||||||.||||||||||||
Mouse   579 ERVLSVLLNELDGVGVRTVERRGSKASQQECQEILSRSVMIVVATNRPDVLDDALLRPGRLDKII 643

Human   649 YIPPPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATT 713
            |:||||.:||||||||||..||:|||||||||||||||||||||||||.||||.|||||||:|||
Mouse   644 YVPPPDQEGRLSILKVCTNNMPVGPDVSLENLAAETCFFSGADLRNLCKEAALFALQENGLEATT 708

Human   714 VKQEHFLKSLKTVKPSLSCKDLALYENLFKKEGFSNVE 751
            |:||||.::||||||||:.|:|..||||||| |.||:|
Mouse   709 VRQEHFTEALKTVKPSLTLKELTFYENLFKK-GLSNLE 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPATA5L1	NP_076968.2	CDC48	22..746	CDD:273521	582/725 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..203		14/31 (45%)
		AAA	237..367	CDD:278434	118/131 (90%)
		AAA	501..651	CDD:278434	123/149 (83%)
Spata5l1	NP_001028428.2	CDC48	14..738	CDD:273521	585/730 (80%)
		AAA	230..362	CDD:278434	118/131 (90%)
		AAA	496..646	CDD:278434	123/149 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83973748
Domainoid	1	1.000	331	1.000	Domainoid score	I14444
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69369
Inparanoid	1	1.050	1194	1.000	Inparanoid score	I4424
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto124710
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7239
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.490