DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPATA5L1 and cdc-48.1

DIOPT Version :9

Sequence 1:	NP_076968.2	Gene:	SPATA5L1 / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens
Sequence 2:	NP_496273.1	Gene:	cdc-48.1 / 174624	WormBaseID:	WBGene00007352	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	778	Identity:	262/778 - (33%)
Similarity:	402/778 - (51%)	Gaps:	108/778 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    34 AALHALGARLGSAVKISLPDGGSCLCTAWPRRDGADGFVQLDPLCASPGAAVGASRSRRSLSLNR 98
            |.:..||...|.||.:.           ..:|..:...:..|..|  |...|..:|..|:....|
Worm    50 AKMDELGLFRGDAVILK-----------GKKRKESVAIIVSDESC--PNEKVRMNRVVRNNLRIR 101

Human    99 L----LLVPCPPL---RRVAVWPVLRERAGAPGARNTAAVLEAAQELLRNRPISLGHVVVAPPGA 156
            |    .:.|.|.|   .|:.|.|:.....|..|  |...|......|...||:..|.:..
Worm   102 LGDVVSITPAPNLSYGTRIHVLPIDDTIEGLTG--NLFDVFLKPYFLEAYRPLHKGDIFT----- 159

Human   157 PGLVAALHIVG---GTPSPDPAGLVTPRTRVSLGGEPPSEAQPQPEV------PLGGLSEAADSL 212
              :.||:..|.   ....|.||.:|:|.|.:...|:|....:.:..:      .|||:.:....:
Worm   160 --VQAAMRTVEFKVVETEPAPACIVSPDTMIHYEGDPIKREEEEESMNDIGYDDLGGVRKQLAQI 222

Human   213 RELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGE 277
            :|::.||||:|:...|:|:..|||:||.||||.|||.:.||||.|.|:....::.|.:.....||
Worm   223 KEMVELPLRHPQLFKAIGIKPPRGILLFGPPGTGKTLIARAVANETGSFFFLINGPEVMSKMSGE 287

Human   278 TEENVRRVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPESRVVAQVLTLLDGASGDREVVV 340
            :|.|:|:.|:   |.....|::||:||:||:.|:|  .:...|.|:|:|:|||:||..|...:||
Worm   288 SESNLRKAFE---ECEKNQPAILFIDEIDAIAPKREKTNGEVERRIVSQLLTLMDGVKGRSNLVV 349

Human   341 VGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVG 405
            :.|||||:::|.||||.||||||:.||.|....|.|||::.|..|.::..|||..:|....|:||
Worm   350 IAATNRPNSIDGALRRFGRFDREIDIGIPDAVGRLEILRIHTKNMKLADDVDLEQIANECHGFVG 414

Human   406 ADLTALCREAAMH------ALLHSEKNQ-DNPVIDEIDF-LEAFKNIQ----PSSFRSVIGLMDI 458
            |||.:||.|||:.      .|:..|.:| |..|::.:.. :|.|:..|    ||:.|..:  ::.
Worm   415 ADLASLCSEAALQQIREKMELIDLEDDQIDAEVLNSLAVTMENFRFAQGKSSPSALREAV--VET 477

Human   459 KPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALATSCH 523
            ....|.:||||::||.:|::.:::|::.|.::::.|:...:|||.||||||.||.|.:|:|..|.
Worm   478 PNTTWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQ 542

Human   524 CSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGAR--SASKTGCDVQERV 586
            .:|:|:.|.:|.:.:.|:||..:..:|.:|||:.|.:||.||:|||..||  .|...|....:||
Worm   543 ANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVLFFDELDSIAKARGGGAGGDGGGASDRV 607

Human   587 LSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIP 651
            ::.:|.|:||:..|                   ::|.||.||||||::|.|:|||||||::||||
Worm   608 INQVLTEMDGMNAK-------------------KNVFIIGATNRPDIIDPAVLRPGRLDQLIYIP 653

Human   652 PPDHKGRLSILKVCTKTMPIGPDVSLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQ 716
            .||...|..|||...:..|:..|:.|..||..|..||||||..:|..|..||::|:......:::
Worm   654 LPDEASRHQILKASLRKTPLSKDLDLTFLAKNTVGFSGADLTEICQRACKLAIRESIEKEIRIEK 718

Human   717 E--------------------------HFLKSLKTVKPSLSCKDLALYE----NLFKKEGFSN 749
            |                          ||.:::|..:.|::..|:..||    .|.:..||.|
Worm   719 ERQDRQARGEELMEDDAVDPVPEITRAHFEEAMKFARRSVTDNDIRKYEMFAQTLQQSRGFGN 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPATA5L1	NP_076968.2	CDC48	22..746	CDD:273521	259/773 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..203		8/37 (22%)
		AAA	237..367	CDD:278434	60/131 (46%)
		AAA	501..651	CDD:278434	64/151 (42%)
cdc-48.1	NP_496273.1	CDC48_N	31..112	CDD:280513	16/74 (22%)
		CDC48	52..775	CDD:273521	258/768 (34%)
		CDC48_2	137..197	CDD:215011	16/66 (24%)
		AAA	247..376	CDD:278434	60/131 (46%)
		AAA	520..654	CDD:278434	65/152 (43%)
		Vps4_C	<727..771	CDD:286426	7/43 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161452058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750