DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gmip and cv-c

DIOPT Version :9

Sequence 1:	XP_030099716.1	Gene:	Gmip / 78816	MGIID:	1926066	Length:	1002	Species:	Mus musculus
Sequence 2:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	1206	Identity:	245/1206 - (20%)
Similarity:	391/1206 - (32%)	Gaps:	403/1206 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 HWLAHVFLHFPPPELTPAPEGRK---RYSDIFQSLDNLEISLGNVTFDPLAGDPVRREDLEPDKA 67
            |.|.|  .|.|.|.:.|    ||   .:....:|.:..::||           .:|:|..:...:
  Fly  1252 HSLDH--YHSPQPLVHP----RKVLPIHHHALKSKERGQLSL-----------VLRQEPFQSLLS 1299

Mouse    68 DTATVVTE--------ENSEASSWRDLSPEG------------PAPLTEEELDLRLIRTKGGVDA 112
            .:||...:        ..|.||....|...|            |..|.|.|:..|....: ....
  Fly  1300 PSATAANQLHHFVELPSPSSASLHSGLGDSGGIQELCTKSNSAPMLLKEREMSRRFDNFE-AQHL 1363

Mouse   113 ALEYAKAWS-RYAKELLAWTDKRANYELEFAKSIMKLAEAGKVSILQQSQMPLQYIYT----LFL 172
            .|.|:::.| ||..|:.|         :|..|.:..........:.:..|.|:.....    ..|
  Fly  1364 TLRYSRSQSDRYLAEIEA---------VEACKWLRAAGFPQYAQMYEDHQFPIDLNNVAKDHTNL 1419

Mouse   173 EHDLSLGAL-----ALETVAQQKRDY-YQPLAAKRMEIEKWRKEF--KEQW-----LKEQKRMNE 224
            |:| .|.:|     .|...|..:.|. ::|...::.| |...:.|  .|.|     ::...|:.|
  Fly  1420 END-QLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKE-ESDDENFALSEHWTFQPHIRRWSRIGE 1482

Mouse   225 AVQALRRSELQYIQRREDLRARSQGSP----ED-----------------PPSQASPGSNKQQER 268
            ....|....|..:...:...:..:.||    ||                 |...:|.|......|
  Fly  1483 MGLELPPPGLLSLNVEKTESSSKESSPDRFEEDGAGITLVTPGCSKAGGIPNDGSSLGEGSDSGR 1547

Mouse   269 RRRSREEA---QAKAHEAEALYQACVREANSRQQDLETTKRRIVSHVRKLVLQGDEVLRRVTLGL 330
            .|||..|.   |||         |.:|...|.:     ::||...:...:|:.|..||   .|..
  Fly  1548 LRRSGSERIKDQAK---------ALLRRVESIK-----SRRRKRQNRENVVISGPTVL---DLSQ 1595

Mouse   331 FELRGAQAERGPRSFSALAECCVPFEPGQRYQEFVRTLQPGA--PPPPSPAFCFQEFTAVVHSFP 393
            |                          |||..    ..:|.|  ..||||:     ..:.:|:||
  Fly  1596 F--------------------------GQRSS----LRKPDAVYSTPPSPS-----ALSPMHTFP 1625

Mouse   394 QDTKKKFSG---PLPPRLE-----EEGSPEPGPWEVASLGSQGI-----PGSDVDSVGGGSESRS 445
               |..|.|   .:|...:     ...||:..|....|:.:..:     |.|.:.. |...:|.|
  Fly  1626 ---KAPFFGNDLKVPSHSDNFLSPNRSSPKRTPTTPRSMRTSPLHFFSSPMSQLKE-GKSDDSSS 1686

Mouse   446 L--DSPTSSPG--------AGARRLV----KASSTGTESSDDFEE-------------------- 476
            .  ||..||.|        :.|||.:    |....|..|..:..:
  Fly  1687 YYSDSQESSTGGKLSLRKPSKARRFLQRTGKVDDIGAHSDSECHQGRKLLIKDANSNTTEVKVKK 1751

Mouse   477 ----------RDPDLGDGIENGVGSPFRKWTLS---------TAAQTHRLRRLRGPAKCRECEAF 522
                      :||...||..:   |.||..:.|         ||..|......|.|..  ...:|
  Fly  1752 LTRGGSLNLGKDPKKRDGFRS---SSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVV--RWHSF 1811

Mouse   523 MVSGTECEE----CFLTCHKRCLE-------------------------TLLILCGH--RRLPAR 556
                 :.||    .|..|..:.:|                         .|:.|.||  |..|:.
  Fly  1812 -----QMEERPNMIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSH 1871

Mouse   557 MS----------------------LFGVDFLQLPRDFPEEVPFVITRCTAEIEHRALGLQGIYRV 599
            .|                      :|||..|.:.:...:.:|..:......::..||...||:|.
  Fly  1872 RSGWNWELPKFIKKIKMPDYKDKKVFGVPLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRK 1936

Mouse   600 SGSRVRVERLCQAFENGRALVELSG----NSPHDITSVLKRFLQELTDPVVPFHLYDAFISLAKT 660
            ||.:.|:.:|.:..|...:..|...    ...:|:..:||::.:||.:.::...:.:.|:::.:.
  Fly  1937 SGGKSRIMKLREQIEVTDSTAECMDVFDLQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQH 2001

Mouse   661 LHADPGDDPGTPNPSPEIIRSLKTLLVQLPDSNYSTLRHLVAHLFRVAARFEENKMSANNLGIVF 725
            |            |:...:.:::..::.|||.|...|..|:..|..|||..::|:|::||||:..
  Fly  2002 L------------PAEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCL 2054

Mouse   726 GPTLLRP--PDGPRATGASP-----------VACLLDSGHQAQLVEFLIVHYEQIFGMDELPLAS 777
            ..::...  ..|..:..|||           :..|.::....:.:.|:|.||:||:     ..|.
  Fly  2055 AQSIFHSSISTGSASVSASPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIY-----TAAK 2114

Mouse   778 EPLTQDPGLAPAC----LESSPQHPASLLAQDTQ---------------------------PLTI 811
            |.|::       |    :|.|...|...|.:..|                           .:..
  Fly  2115 EKLSK-------CNFSYMEESKPLPLEALGEGMQFHNWRGYLYECTSATIKEGREKTRGWFSINS 2172

Mouse   812 ALDSSPD-------PKHHSALEKC-PEVTPPEKSLNRDFAIGSHVLGF-----------FLQLAT 857
            ..|||.|       ..|...|.:| .|:..|.|          .||.|           .||..|
  Fly  2173 LNDSSVDIAYKKVGDGHPLRLWRCSTEIEGPPK----------EVLEFVIKQRASWDTNLLQCQT 2227

Mouse   858 LQR-DQREEEVEDTRDGAGDGSSHC-----PEDLALGA-----QSRGHFSRQPVKYSRGGVRPVT 911
            ::: |.|.|..:...||... :..|     ..||..||     .|..|...:|:   .|.||.|.
  Fly  2228 VKKLDDRTEIYQYALDGQLT-TDFCVLRSWQTDLPRGACVIVETSIDHAKAKPL---FGAVRGVV 2288

Mouse   912 HQLSSLALVASKLCEETPVTVSAVHRGSLRVRGLGP 947
              |:|..|:  :.|......|  :|...:.|:|..|
  Fly  2289 --LASRYLI--EPCGSGRSRV--MHLARVDVKGKTP 2318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gmip	XP_030099716.1	BAR	124..324	CDD:386243	47/240 (20%)
		C1	503..548	CDD:197519	10/73 (14%)
		RhoGAP	560..763	CDD:383032	47/219 (21%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	11/59 (19%)
		RhoGAP_DLC1	1893..2116	CDD:239840	52/239 (22%)
		SRPBCC	2148..2343	CDD:301327	42/191 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030