Protein Alignment KCNAB1 and CG12224

DIOPT Version :10

• Sequence 1: NP_751892.1
• Gene: KCNAB1 / 7881
• HGNCID: 6228
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_650139.4
• Gene: CG12224 / 41453
• FlyBaseID: FBgn0037974
• Length: 339
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 84/346 - (24%)
• Similarity: 150/346 - (43%)
• Gaps: 62/346 - (17%)

Human    89 MPHRNLGKSGLRVSCLGLGTWVTFGGQISD------EVAERLMTI--AYESGVNLFDTAEVYAAG 145
            |.:|.||.:||.||.|.:|     |..:.:      :..|.::.:  |..||:|..|||..|  |
  Fly    22 MEYRQLGSTGLHVSKLAIG-----GSPLCNLFFDDYDREEGILMVQEAIRSGINYIDTAPFY--G 79

Human   146 KAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHII--------EGLKGSLQRLQLE 202
            ::||:||..:|..  .|.:..|.||:       ...||..|::.        |.:|.||:||||:
  Fly    80 QSEVLLGQALKDV--PREAYYIATKV-------ARYGLDPKNMFDYSADKARESVKRSLERLQLD 135

Human   203 YVDVVFAN----RPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPV 263
            .||::..:    .|:.:..:.|.:..:...:..|.|.:.|.:.:....:.|.  ..|....|..|
  Fly   136 RVDILQVHDVDAAPNLDIVLNETIPVLEEYVQAGKARFIGVTAYDVDVLKEC--AERGKGRIQVV 198

Human   264 CEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 328
            ...|.|.|.  :...::..:.:.|:|||.:..:..:.|::.    |..|.:|...       .:.
  Fly   199 LNYARYTLL--DNTLLRYMKDFQKMGVGVVCAAAHSLGLLR----NAGPHASHPG-------SQE 250

Human   329 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLP 393
            |::...|..:        |.::....|.:||:.:.::.:|.::.|:|....:.|..||.||  ..
  Fly   251 ILAVAKRGAE--------ICQQRNVELGKLAMYYTMQLDGAATFLIGIPNRKLLRINLDAI--FD 305

Human   394 KMTSHVVNEIDNILRNKPYSK 414
            .:||| ..|:...||...::|
  Fly   306 GLTSH-EQEVLQYLRENVFTK 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNAB1	NP_751892.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		AKR_KCAB1B_AKR6A3-like	89..411	CDD:381385	83/341 (24%)
CG12224	NP_650139.4	AKR_galDH	22..313	CDD:381389	80/332 (24%)