Protein Alignment KCNAB1 and Hk

DIOPT Version :10

• Sequence 1: NP_751892.1
• Gene: KCNAB1 / 7881
• HGNCID: 6228
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_001259401.1
• Gene: Hk / 31955
• FlyBaseID: FBgn0263220
• Length: 887
• Species: Drosophila melanogaster
• Alignment Length: 354
• Identity: 168/354 - (47%)
• Similarity: 247/354 - (69%)
• Gaps: 28/354 - (7%)

Human    77 LSSEHTTVCTTGMPHRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEV 141
            |...|.:..|.|:.::||||||||:|.:|||||..|...:||:.||.::.:|.|||:||||.:|.
  Fly   191 LPLRHGSTPTPGLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEA 255

Human   142 YAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDV 206
            :    :|..:|.|:::.||:|::.|||||:||..|:| |||||||||||.::.|||||||:|:|:
  Fly   256 H----SETEIGKILQRAGWKRTAYVITTKVYWSTKSE-ERGLSRKHIIECVRASLQRLQLQYIDI 315

Human   207 VFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHL 271
            |..::.|...|| |:||||::||.||.||||||:|||.:||||||:..||||.|.|:.||:|||:
  Fly   316 VIIHKADPMCPM-EVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVEQSEYHM 379

Human   272 FQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNG--VPESSRASLKCYQWL--------- 325
            |.|||.|:.|||:|:|||||.|.|.||:..:...:.|:.  :|:.| ...|.:.|.
  Fly   380 FCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGS-FKTKSFSWTEDEINRNAA 443

Human   326 --------KERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQL 382
                    |:||  :|||:..::|:||:.:||:|||:..||::||.|::|.|..:|||:::.|||
  Fly   444 LSPQGSWGKDRI--DEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQL 506

Human   383 IENLGAIQVLPKMTSHVVNEIDNILRNKP 411
            .::|.::|:||:::|.|:.|::.||.|||
  Fly   507 HQSLQSLQLLPRLSSSVMLELERILENKP 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNAB1	NP_751892.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		AKR_KCAB1B_AKR6A3-like	89..411	CDD:381385	162/340 (48%)
Hk	NP_001259401.1	AKR_AKR6B1	203..535	CDD:381368	162/340 (48%)