Protein Alignment RAB7A and RabX6

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_001261219.1
• Gene: RabX6 / 38084
• FlyBaseID: FBgn0035155
• Length: 222
• Species: Drosophila melanogaster
• Alignment Length: 213
• Identity: 62/213 - (29%)
• Similarity: 108/213 - (50%)
• Gaps: 24/213 - (11%)

Human    10 KVIILGDSGVGKTSLMNQYVNKKF--SNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQS 72
            |||:.||.||||:||..::....|  ....|:|:|.|.:.:|..|:::.:.:|:|||.|.||..|
  Fly    10 KVILCGDYGVGKSSLFRRFATNTFITDTDRKSTLGLDHIDREYSVNEKQIKLQLWDTGGMERVAS 74

Human    73 LGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENR--QVA 135
            :..::|:.|:..:|||.:....:|.:|.....:.:..|     ||....:.|||.||:.|  :|:
  Fly    75 VTSSYYKFAEGAILVFALDNAASFHSLSQHLLDIVTYA-----ENAKIFICGNKSDLDGREPEVS 134

Human   136 TKRAQAWCYSKNNI--PYFETSAKEAINVEQAFQTIAR-----NALKQETEVELYNEFPEPIKLD 193
            .:..:|:|...:::  ..::||.:....||:.|:.|:|     |..|.|.:...:..|    ::|
  Fly   135 DEEVEAFCEQCHSLISATYKTSCRSGAGVEEMFRDISRQLVHANRSKMELQALEHKSF----QVD 195

Human   194 KNDRAKAS----AESCSC 207
            ......|:    |.||.|
  Fly   196 TASSGAATNEEDASSCGC 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	55/179 (31%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		2/14 (14%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		4/14 (29%)
RabX6	NP_001261219.1	Rab	10..172	CDD:206640	51/166 (31%)