Protein Alignment RAB7A and Rab32

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_525109.1
• Gene: Rab32 / 35940
• FlyBaseID: FBgn0002567
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 71/214 - (33%)
• Similarity: 118/214 - (55%)
• Gaps: 7/214 - (3%)

Human     1 MTS---RKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVD-DRLVTMQI 61
            |||   :::.|.|::::|:.|.||||.:.:||::.||..|:||||.||..|.:..| :.:|.:|:
  Fly   473 MTSTSDKREHLYKILVIGELGTGKTSFIKRYVHQFFSQNYRATIGVDFALKVLQWDANTIVRLQL 537

Human    62 WDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNK 126
            ||.||||||.::...:|:.|....:|||||...||..:..|:::...:....|....|.::|.||
  Fly   538 WDIAGQERFGNMTRVYYKEAVGAFIVFDVTRSGTFDCVSKWKEDLDSKVQLPDGSPIPCILLANK 602

Human   127 IDLENRQVATKRAQAWCYSKNN--IPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEP 189
            .|.|.:.:.|:..:...|.:.|  ..:|||||||.||:::|.:.:....|..:..:.......:.
  Fly   603 CDQEKQGIITQPEKMDEYVRENGFAGWFETSAKENINIDEAARALVNKILINDKLISADLADGDK 667

Human   190 IKLDKNDRAKASAES-CSC 207
            ..|...|...:.|:: |||
  Fly   668 FNLSAADATGSDAKNKCSC 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	61/172 (35%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		6/12 (50%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		5/14 (36%)
Rab32	NP_525109.1	PHA03247	<126..481	CDD:223021	3/7 (43%)
		Rab32_Rab38	484..686	CDD:206692	65/201 (32%)