Protein Alignment RAB7A and Rab6

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_477172.1
• Gene: Rab6 / 34636
• FlyBaseID: FBgn0015797
• Length: 208
• Species: Drosophila melanogaster
• Alignment Length: 201
• Identity: 73/201 - (36%)
• Similarity: 116/201 - (57%)
• Gaps: 9/201 - (4%)

Human    10 KVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLG 74
            |::.||:..||||||:.:::...|.|.|:||||.|||:|.:.::||.|.:|:|||||||||:||.
  Fly    14 KLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLI 78

Human    75 VAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDL-ENRQVATKR 138
            .::.|.:...|:|:|:|..|:|.....|.|:...:..    .:...:::|||.|| :.|||:|:.
  Fly    79 PSYIRDSTVAVVVYDITNTNSFHQTSKWIDDVRTERG----SDVIIMLVGNKTDLSDKRQVSTEE 139

Human   139 AQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNAL--KQETEVELYNEFPEPIKLDKNDRAKAS 201
            .:... .:.|:.:.|||||...||:|.|:.:|. ||  ...||.:...:..|.:..|..:..|..
  Fly   140 GERKA-KELNVMFIETSAKAGYNVKQLFRRVAA-ALPGMDSTENKPSEDMQEVVLKDSPNETKDP 202

Human   202 AESCSC 207
            ...|:|
  Fly   203 EGGCAC 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	66/171 (39%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		4/12 (33%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		7/14 (50%)
Rab6	NP_477172.1	Rab6	13..173	CDD:206654	64/164 (39%)