Protein Alignment RAB7A and Rab10

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_523419.1
• Gene: Rab10 / 33025
• FlyBaseID: FBgn0015789
• Length: 204
• Species: Drosophila melanogaster
• Alignment Length: 201
• Identity: 69/201 - (34%)
• Similarity: 117/201 - (58%)
• Gaps: 5/201 - (2%)

Human     7 VLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQ 71
            :|.|::::||||||||.::.::.:..|::.:.:|||.||..|.|.:..:.:.:|||||||||||.
  Fly     8 LLFKLLLIGDSGVGKTCILFRFSDDAFTSTFISTIGIDFKIKTVELRGKKIKLQIWDTAGQERFH 72

Human    72 SLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVAT 136
            ::..::||||...:||:|:|...:|:.:..|    |........|:...::||||.|:.:::|..
  Fly    73 TITTSYYRGAMGIMLVYDITNEKSFENIVKW----LRNIDEHANEDVEKMILGNKCDMTDKRVVN 133

Human   137 KRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKAS 201
            |........::.|.:.|||||..||:|:||..:| .|:..:|......|..|.:.:|:.::.||.
  Fly   134 KERGEAIAREHGIRFMETSAKSNINIERAFCELA-EAILDKTSGRESAENQERVIIDRRNQEKAP 197

Human   202 AESCSC 207
            ..|..|
  Fly   198 GYSKCC 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	60/169 (36%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		1/12 (8%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		7/14 (50%)
Rab10	NP_523419.1	Rab8_Rab10_Rab13_like	7..173	CDD:206659	61/169 (36%)