Protein Alignment RAB7A and Rab35

DIOPT Version :10

• Sequence 1: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Sequence 2: NP_608373.1
• Gene: Rab35 / 33014
• FlyBaseID: FBgn0031090
• Length: 201
• Species: Drosophila melanogaster
• Alignment Length: 199
• Identity: 73/199 - (36%)
• Similarity: 113/199 - (56%)
• Gaps: 7/199 - (3%)

Human     8 LLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQS 72
            |.|::|:|||||||:||:.::.:..||..|..|||.||..:.|.::...|.:|||||||||||::
  Fly     8 LFKLLIIGDSGVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMRVKLQIWDTAGQERFRT 72

Human    73 LGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVA-T 136
            :...:|||....::|:|||...:|..:..|.:|  ||   .:.:....|::|||.|..:|:|. |
  Fly    73 ITSTYYRGTHGVIVVYDVTNGESFANVRRWLEE--IQ---NNCDVVKKVLVGNKNDDPDRKVVIT 132

Human   137 KRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKAS 201
            :.||.:. .:.:|..||||||:.||||..|.:|.|..|..:.......:..:.:.|..|.:....
  Fly   133 EDAQRFA-KQMDIELFETSAKDNINVENMFLSITRQVLDHKLRTSPNEQQKDTLHLKPNPKGSKG 196

Human   202 AESC 205
            .:.|
  Fly   197 GKCC 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	69/170 (41%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		3/12 (25%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		7/14 (50%)
Rab35	NP_608373.1	Rab35	3..201	CDD:133310	73/199 (37%)